catalog number :
MBS135003
products full name :
Mouse monoclonal to human vitronectin
products short name :
[vitronectin]
other names :
[vitronectin; Vitronectin; vitronectin; epibolin; S-protein; somatomedin B; complement S-protein; serum spreading factor; serum-spreading factor; vitronectin; S-protein; Serum-spreading factor; V75]
products gene name :
[VTN]
other gene names :
[VTN; VTN; VN; V75; VNT; VN]
uniprot entry name :
VTNC_HUMAN
concentration :
6.3 mg/ml . Aliquot: 1 x 1.0mg. Volume: 0.158 ml
storage stability :
Store at -70 degree C. Shelf Life: 5 years from delivery
tested application :
Western Blot (WB)
other info1 :
Immunogen: Full length native protein (purified) (Human). Target Information: Recognises Vitronectin. Target Molecular Weight: 75,000
other info2 :
Buffer: 0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6. Extinction Coefficient: 1.36. Antigen: Full length native protein (purified) (Human).
products categories :
Vitronectin; Monoclonal Antibodies to Human Vitronectin
products description :
WB: Reduced and non-reduced monomeric vitronectin
ncbi acc num :
NP_000629.3
ncbi gb acc num :
NM_000638.3
ncbi mol weight :
160,000
ncbi pathways :
ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262); FOXA1 Transcription Factor Network Pathway (137979); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Inflammatory Response Pathway (198766); Integrin Cell Surface Interactions Pathway (106110)
ncbi summary :
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
uniprot summary :
VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Protein type: Secreted, signal peptide; Cell adhesion; Motility/polarity/chemotaxis; Secreted. Chromosomal Location of Human Ortholog: 17q11. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: integrin binding; heparin binding; protein binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding. Biological Process: receptor-mediated endocytosis; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; negative regulation of blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of receptor-mediated endocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of complement activation; cell adhesion mediated by integrin; innate immune response; immune response; cell adhesion