catalog number :
MBS1324934
products type :
Recombinant Protein
products full name :
Recombinant Mouse Histone deacetylase complex subunit SAP130
products short name :
Histone deacetylase complex subunit SAP130
products name syn :
130 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p130
other names :
histone deacetylase complex subunit SAP130; Histone deacetylase complex subunit SAP130; histone deacetylase complex subunit SAP130; Sin3A associated protein; 130 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p130
products gene name :
Sap130
other gene names :
Sap130; Sap130; 6720406D06; 2610304F09Rik
uniprot entry name :
SP130_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
845 – 1057;Interactions with SIN3A and HDAC1 region.
sequence :
PRKQQHVISTEEGDMMETNSTDDEKSAAKSLLVKAEKRK
SPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHH
FQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCA
AQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRI
NELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLL
NKNGTVKKVSKLKRKEKV
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info2 :
Species: Mus musculus (Mouse)
products description :
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes
products references :
The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.
Science 309:1559-1563(2005)
ncbi acc num :
NP_766553.1
ncbi gb acc num :
NM_172965.2
ncbi mol weight :
28.87kD
uniprot summary :
SAP130: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Belongs to the SAP130 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Acetyltransferase. Cellular Component: nucleoplasm; nucleus. Molecular Function: histone acetyltransferase activity; protein binding; transcription coactivator activity. Biological Process: negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent