Rabbit Anti-STAT3 (Ab-705) Polyclonal Antibody | MyBioSource MBS132110 product information

product summary

request information :

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-STAT3 (Ab-705) Polyclonal Antibody

catalog :

MBS132110

quantity :

0.04 mg

price :

140 USD

clonality :

polyclonal

host :

rabbit

reactivity :

mouse, rat, human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS132110

products type :

Antibody

products full name :

Rabbit Anti-STAT3 (Ab-705) Polyclonal Antibody

products short name :

STAT3

products name syn :

Anti STAT

other names :

Stat3; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3; OTTMUSP00000002052; OTTMUSP00000002053; OTTMUSP00000045315; OTTMUSP00000045316; acute phase response factor; acute-phase response factor; signal transducer and activator of transcription 3; Acute-phase response factor

products gene name :

STAT3

other gene names :

Stat3; Stat3; Aprf; AW109958; 1110034C02Rik; Aprf

uniprot entry name :

STAT3_MOUSE

clonality :

Polyclonal

isotype :

Rabbit IgG

host :

Rabbit

reactivity :

Human, mouse, rat

sequence length :

770

specificity :

STAT3 (Ab-705) antibody detects endogenous levels of total STAT3 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

concentration :

1 ug/ul in phosphate buffered saline (without Mg2+

storage stability :

Store at -20 degree C/1 year

tested application :

Immunohistochemistry, Western Blot

app notes :

WB: 1: 500-1:1,000. IHC: 1:50-1:100

other info1 :

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human STAT3 around the phosphorylation site of tyrosine 705 (A-P-YP-L-K). Antigen Species: Human

other info2 :

Conjugation: Unconjugated

products categories :

Cancer/Apoptosis Pathway

ncbi gi num :

458706

uniprot acc num :

P42227

ncbi mol weight :

88,054 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway 83310!!Acute Myeloid Leukemia Pathway 529!!Adipocytokine Signaling Pathway 83290!!Adipocytokine Signaling Pathway 505!!Adipogenesis Pathway 198299!!Androgen Receptor Signaling Pathway 198319!!B Cell Receptor Signaling Pathway 198285!!Chemokine Signaling Pathway 99271!!Chemokine Signaling Pathway 96864!!Delta-Notch Signaling Pathway 198316

ncbi summary :

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

uniprot summary :

Function: Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way. Subunit structure: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with IL31RA, NCOA1, PELP1, SIPAR, SOCS7, STATIP1 and TMF1. Interacts with IL23R in presence of IL23. Interacts (via SH2 domain) with NLK. Interacts with KPNA4 and KPNA5; KPNA4 may be the primary mediator of nuclear import. Interacts with CAV2; the interaction is increased on insulin-induced tyrosine phosphorylation of CAV2 and leads to STAT3 activation. Interacts with ARL2BP; interaction is enhanced with ARL2. By similarity. Interacts with ARL2BP; the interaction is enhanced by LIF and JAK1 expression. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14. Subcellular location: Cytoplasm. Nucleus. Note: Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. By similarity. Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation. Ref.12. Tissue specificity: STAT3A is seen in the liver, spleen, and kidney. STAT3B is also detected in the liver, although in a much less abundant manner. Post-translational modification: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. By similarity. Ref.9 Ref.11 Ref.15. Miscellaneous: Involved in the gp130-mediated signaling pathway. Sequence similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain.

size :

0.04 mg

price :

140 USD

more info or order :

MyBioSource product webpage