antibody

MBTPS1 Polyclonal Antibody

MBS129770

0.05 mL

230 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry

Antibody

MBTPS1 Polyclonal Antibody

MBTPS1

S1P; PCSK8; SKI-1

Membrane-bound transcription factor site-1 protease; Membrane-bound transcription factor site-1 protease; membrane-bound transcription factor site-1 protease; endopeptidase S1P; subtilisin/kexin isozyme-1; proprotein convertase subtilisin/kexin type 8; membrane-bound transcription factor peptidase, site 1; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1

MBTPS1

MBTPS1; MBTPS1; S1P; PCSK8; SKI-1; KIAA0091; S1P; SKI1; SKI-1

MBTP1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1052

Affinity Purification

1mg/ml

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:100

Volume: 0.2ml. Species: Human. Immunogen: Recombinant Protein

Immunogen: Recombinant protein of human MBTPS1. Calculated Molecular Weight: 118kDa

Polyclonal

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.

17368466

Q14703.1

Q14703

1052

ATF6-alpha Activates Chaperones Pathway (105905); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Proteins Pathway (106230); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190); Regulation Of Cholesterol Biosynthesis By SREBP (SREBF) Pathway (685551); SREBP Signalling Pathway (219802); Unfolded Protein Response (UPR) Pathway (105904)

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]

MBTPS1: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Belongs to the peptidase S8 family. Protein type: Membrane protein, integral; Endoplasmic reticulum; EC 3.4.21.112; Protease. Chromosomal Location of Human Ortholog: 16q24. Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; Golgi stack; endoplasmic reticulum lumen; integral to membrane. Molecular Function: serine-type endopeptidase activity. Biological Process: cholesterol metabolic process; regulation of transcription factor import into nucleus; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; membrane protein intracellular domain proteolysis; lysosome organization and biogenesis; unfolded protein response; lipid metabolic process; proteolysis

0.05 mL

230 USD

0.1 mL

305

0.2 mL

460