antibody

ATP6V1E1 Polyclonal Antibody

MBS129541

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunoprecipitation

Antibody

ATP6V1E1 Polyclonal Antibody

[ATP6V1E1]

[P31; Vma4; ATP6E; ATP6E2; ATP6V1E]

[V-type proton ATPase subunit e 1; V-type proton ATPase subunit e 1; V-type proton ATPase subunit e 1; V-ATPase H subunit; V-ATPase subunit e 1; V-ATPase M9.2 subunit; vacuolar proton pump H subunit; vacuolar ATP synthase subunit H; vacuolar proton pump subunit e 1; vacuolar proton-ATPase subunit M9.2; V-ATPase 9.2 kDa membrane accessory protein; H(+)-transporting two-sector ATPase, subunit H; ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1; V-ATPase 9.2 kDa membrane accessory protein; V-ATPase M9.2 subunit; Vacuolar proton pump subunit e 1]

[ATP6V1E1]

[ATP6V0E1; ATP6V0E1; M9.2; ATP6H; Vma21; Vma21p; ATP6V0E; ATP6H; ATP6V0E; V-ATPase subunit e 1]

VA0E1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

81

Affinity Purification

Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

WB: 1:500-1:2000. IP: 1:20-1:50. IHC: 1:50-1:200

Western Blot (WB)

Category: Primary antibody. Species: Human

Immunogen: Recombinant protein of human ATP6V1E1. Calculated Molecular Weight: 26kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Polyclonal

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.

3024811

P36543

Collecting Duct Acid Secretion Pathway (147586); Collecting Duct Acid Secretion Pathway (147560); Disease Pathway (530764); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (83102); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (515); Insulin Receptor Recycling Pathway (106438); Iron Uptake And Transport Pathway (187191); Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway (645267); Metabolic Pathways (132956); Oxidative Phosphorylation Pathway (82942)

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]

ATP6V0E1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase e1/e2 subunit family. Protein type: Transporter, ion channel; Membrane protein, integral; Transporter, iron; Transporter; Hydrolase; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: phagocytic vesicle membrane; membrane; integral to membrane; endosome membrane. Molecular Function: ATPase activity, coupled to transmembrane movement of ions; transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism. Biological Process: interaction with host; vacuolar acidification; proton transport; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; response to amino acid stimulus; cell growth; transmembrane transport

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430