catalog number :
MBS129539
products full name :
RNH1 Polyclonal Antibody
products short name :
[RNH1]
products name syn :
[RAI; RNH]
other names :
[Ribonuclease inhibitor; Ribonuclease inhibitor; ribonuclease inhibitor; placental RNase inhibitor; placental ribonuclease inhibitor; ribonuclease/angiogenin inhibitor 1; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI]
products gene name :
[RNH1]
other gene names :
[RNH1; RNH1; RAI; RNH; PRI; RNH; Placental RNase inhibitor; RAI]
uniprot entry name :
RINI_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20°C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB)
app notes :
WB: 1:100-1:2000
image1 heading :
Western Blot (WB)
other info1 :
. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Immunogen: Recombinant Protein
other info2 :
. Calculated MW: 49kDa. Observed MW: 40kDa
products categories :
Polyclonal
products description :
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988)
ncbi summary :
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
uniprot summary :
RNH1: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Protein type: Inhibitor. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: angiogenin-PRI complex; cytoplasm. Molecular Function: protein binding; ribonuclease inhibitor activity. Biological Process: negative regulation of catalytic activity; mRNA catabolic process; regulation of angiogenesis