antibody

STEAP4 Polyclonal Antibody

MBS129482

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, immunohistochemistry

Antibody

STEAP4 Polyclonal Antibody

[STEAP4]

[TIARP; STAMP2; TNFAIP9]

[Metalloreductase STEAP4; Metalloreductase STEAP4; metalloreductase STEAP4; six transmembrane prostate protein 2; sixTransMembrane protein of prostate 2; tumor necrosis factor, alpha-induced protein 9; six-transmembrane epithelial antigen of prostate 4; tumor necrosis-alpha-induced adipose-related protein; STEAP family member 4; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9]

[STEAP4]

[STEAP4; STEAP4; TIARP; STAMP2; TNFAIP9; STAMP2; TNFAIP9]

STEA4_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

459

Affinity Purification

Store at -20 degree C. Avoid freeze / thaw cycles

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000. IHC: 1:50-1:200

Western Blot (WB)

Category: Primary Antibody. Immunogen: A synthetic peptide of human STEAP4.

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Polyclonal

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

74748242

Q687X5.1

Q687X5

52kDa

The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

STEAP4: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 1.16.1.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 7q21.12. Cellular Component: Golgi membrane; integral to membrane; plasma membrane; endosome. Molecular Function: metal ion binding; cupric reductase activity. Biological Process: fat cell differentiation; iron ion homeostasis; copper ion import

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430