product summary
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company name :
MyBioSource
product type :
antibody
product name :
CLCNKA Polyclonal Antibody
catalog :
MBS129305
quantity :
0.05 mL
price :
285 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
product information
catalog number :
MBS129305
products type :
Antibody
products full name :
CLCNKA Polyclonal Antibody
products short name :
CLCNKA
products name syn :
CLCK1; ClC-K1; hClC-Ka
other names :
Chloride channel protein ClC-Ka; Chloride channel protein ClC-Ka; chloride channel protein ClC-Ka; chloride channel Ka; chloride channel, kidney, A; chloride channel, voltage-sensitive Ka; ClC-K1
products gene name :
CLCNKA
other gene names :
CLCNKA; CLCNKA; CLCK1; ClC-K1; hClC-Ka; Chloride channel Ka
uniprot entry name :
CLCKA_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
687
purity :
Affinity Purification
concentration :
1mg/ml
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Immunogen: Recombinant protein of human CLCNKA. Calculated Molecular Weight: 75kDa
products categories :
Polyclonal
products description :
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.
ncbi gi num :
1705857
ncbi acc num :
P51800.1
uniprot acc num :
P51800
ncbi mol weight :
687
ncbi pathways :
Ion Channel Transport Pathway (187193); Stimuli-sensing Channels Pathway (771568); Transmembrane Transport Of Small Molecules Pathway (106572)
ncbi summary :
This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
CLCNKA: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKA are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter. Chromosomal Location of Human Ortholog: 1p36. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: metal ion binding; voltage-gated chloride channel activity. Biological Process: transport; excretion; transmembrane transport. Disease: Bartter Syndrome, Type 4b
size1 :
0.05 mL
price1 :
285 USD
size2 :
0.2 mL
price2 :
555
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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