antibody

TMEM173 Polyclonal Antibody

MBS129300

0.05 mL

285 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS

Antibody

TMEM173 Polyclonal Antibody

TMEM173

ERIS; MITA; MPYS; NET23; STING

Stimulator of interferon genes protein; Stimulator of interferon genes protein; stimulator of interferon genes protein; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; transmembrane protein 173; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173

TMEM173

TMEM173; TMEM173; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; ERIS; MITA; STING; hSTING; ERIS; hMITA

STING_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

379

Affinity Purification

1mg/ml

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200. FC: 1:20 - 1:50

Species: Human. Immunogen: Recombinant Protein

Immunogen: Recombinant protein of human TMEM173. Calculated Molecular Weight: 42kDa

Polyclonal

TMEM173, also named as ERIS, MITA, STING and MPYS, is a facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. There're monomer (40 kDa) and dimer (80 kDa) form of TMEM173 in western blot test.

74727720

Q86WV6.1

Q86WV6

379

Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); IRF3 Mediated Activation Of Type 1 IFN Pathway (576257); IRF3-mediated Induction Of Type I IFN Pathway (833819); Immune System Pathway (106386); Innate Immune System Pathway (106387); RIG-I-like Receptor Signaling Pathway (117292); RIG-I-like Receptor Signaling Pathway (116128); Regulation Of Innate Immune Responses To Cytosolic DNA Pathway (833823)

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; Lys-63 -linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family. Protein type: Mitochondrial; Membrane protein, multi-pass; Apoptosis; Membrane protein, integral; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 5q31.2. Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial outer membrane; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; peroxisome. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; transcription factor binding; protein kinase binding. Biological Process: regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; apoptosis; positive regulation of interferon type I production; positive regulation of transcription factor import into nucleus; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; activation of innate immune response; defense response to virus; interferon-beta production. Disease: Sting-associated Vasculopathy, Infantile-onset

0.05 mL

285 USD

0.2 mL

555