product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Mouse Interleukin-1 receptor-associated kinase 4 (Irak4)
catalog :
MBS1292509
quantity :
0.05 mg (E-Coli)
price :
875 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1292509
products type :
Recombinant Protein
products full name :
Recombinant Mouse Interleukin-1 receptor-associated kinase 4 (Irak4)
products short name :
[Interleukin-1 receptor-associated kinase 4 (Irak4)]
other names :
[interleukin-1 receptor-associated kinase 4; Interleukin-1 receptor-associated kinase 4; interleukin-1 receptor-associated kinase 4; interleukin-1 receptor-associated kinase 4]
products gene name :
[Irak4]
products gene name syn :
[Irak4]
other gene names :
[Irak4; Irak4; IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik; IRAK-4]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[1-459. Full Length]
sequence :
MNKPLTPSTYIRNLNVGILRKLSDFIDPQEGWKKLAVAI
KKPSGDDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTN
CTVGDLVDLLVQIELFAPATLLLPDAVPQTVKSLPPREA
ATVAQTHGPCQEKDRTSVMPMPKLEHSCEPPDSSSPDNR
SVESSDTRFHSFSFHELKSITNNFDEQPASAGGNRMGEG
GFGVVYKGCVNNTIVAVKKLGAMVEISTEELKQQFDQEI
KVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDR
LSCLDGTPPLSWHTRCKVAQGTANGIRFLHENHHIHRDI
KSANILLDKDFTAKISDFGLARASARLAQTVMTSRIVGT
TAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDEN
REPQLLLDIKEEIEDEEKTIEDYTDEKMSDADPASVEAM
YSAASQCLHEKKNRRPDIAKVQQLLQEMSA
purity :
>85% (SDS-PAGE)
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mouse
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol
ncbi gi num :
23943898
ncbi acc num :
NP_084202.2
ncbi gb acc num :
NM_029926.5
uniprot acc num :
Q8R4K2
ncbi mol weight :
50,872 Da
ncbi pathways :
Apoptosis Pathway (83257); Apoptosis Pathway (470); Apoptosis Signaling Pathway (522973); Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795); IL-1 Signaling Pathway (198360); Immune System Pathway (575095); Influenza A Pathway (217174); Influenza A Pathway (217150); Innate Immune System Pathway (575115)
uniprot summary :
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections ().
size1 :
0.05 mg (E-Coli)
price1 :
875 USD
size2 :
0.05 mg (Yeast)
price2 :
970
size3 :
0.2 mg (E-Coli)
price3 :
1175
size4 :
0.05 mg (Baculovirus)
price4 :
1180
size5 :
0.5 mg (E-Coli)
price5 :
1295
size6 :
0.2 mg (Yeast)
price6 :
1305
size7 :
0.05 mg (Mammalian-Cell)
price7 :
1420
size8 :
0.5 mg (Yeast)
price8 :
1475
size9 :
0.1 mg (Baculovirus)
price9 :
1705
size10 :
1 mg (E-Coli)
price10 :
1965
size11 :
0.5 mg (Baculovirus)
price11 :
2215
size12 :
0.1 mg (Mammalian-Cell)
price12 :
2300
size13 :
1 mg (Yeast)
price13 :
2330
size14 :
1 mg (Baculovirus)
price14 :
3415
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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