catalog number :
MBS129014
products full name :
TMEM27 Polyclonal Antibody
products short name :
TMEM27
products name syn :
NX17; NX-17
other names :
Collectrin; Collectrin; collectrin; kidney-specific membrane protein; transmembrane protein 27; Transmembrane protein 27
products gene name :
TMEM27
other gene names :
TMEM27; TMEM27; NX17; NX-17
uniprot entry name :
TMM27_HUMAN
reactivity :
Human, Mouse
purity :
Affinity Purification
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IF: 1:50 - 1:100
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Immunogen: Recombinant protein of human TMEM27. Calculated Molecular Weight: 25kDa
products categories :
Polyclonal
products description :
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells.
ncbi summary :
This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]
uniprot summary :
TMEM27: Regulator of SNARE complex function. Stimulator of beta cell replication. Belongs to the TMEM27 family. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp22. Cellular Component: brush border membrane; cytoplasm; integral to membrane. Molecular Function: peptidyl-dipeptidase activity; protein binding; metallopeptidase activity. Biological Process: positive regulation of calcium ion-dependent exocytosis; proteolysis; positive regulation of amino acid transport