antibody

TLN1 Polyclonal Antibody

MBS128619

0.05 mL

200 USD

polyclonal

unidentified

nonconjugated

Antibody

TLN1 Polyclonal Antibody

[TLN1]

[TLN; ILWEQ]

[Talin-1; Talin-1; talin-1; talin 1]

[TLN1]

[TLN1; TLN1; TLN; ILWEQ; KIAA1027; TLN]

TLN1_HUMAN

polyclonal

IgG

unknown

Human

2541

Affinity Purification

Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

WB: 1:500 - 1:2000

Western Blot (WB)

Immunogen: Recombinant Protein. Category: Primary Antibody. Source: Rabbit

Immunogen: Recombinant protein of human TLN1. Calculated Molecular Weight: 270kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Polyclonal

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

81175200

Q9Y490.3

Q9Y490

2541

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EGF Receptor (ErbB1) Signaling Pathway (137970); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); GRB2:SOS Provides Linkage To MAPK Signaling For Integrins Pathway (106055); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Hemostasis Pathway (106028)

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

Talin-1: a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: ruffle; cell surface; focal adhesion; cytoplasm; plasma membrane; extracellular region; microtubule organizing center; intercellular junction; cytosol. Molecular Function: integrin binding; actin filament binding; LIM domain binding; protein binding; structural constituent of cytoskeleton; insulin receptor binding; vinculin binding. Biological Process: platelet activation; intercellular junction assembly; axon guidance; unfolded protein response; cytoskeletal anchoring; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; platelet degranulation; muscle contraction; cell-substrate junction assembly; cortical actin cytoskeleton organization and biogenesis; cell motility; blood coagulation

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430