Recombinant Human Mucosal addressin cell adhesion molecule 1 | MyBioSource MBS1282932 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Mucosal addressin cell adhesion molecule 1

catalog :

MBS1282932

quantity :

0.05 mg (E-Coli)

price :

180 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1282932

products type :

Recombinant Protein

products full name :

Recombinant Human Mucosal addressin cell adhesion molecule 1

products short name :

Mucosal addressin cell adhesion molecule 1

products name syn :

MAdCAM-1; hMAdCAM-1

other names :

mucosal addressin cell adhesion molecule 1 isoform a; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule 1; mucosal vascular addressin cell adhesion molecule 1

products gene name :

MADCAM1

other gene names :

MADCAM1; MADCAM1; MACAM1; MAdCAM-1; hMAdCAM-1

uniprot entry name :

MADCA_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

19-317; Partial. Provide the complete extracellular domain.

sequence length :

317

sequence :

QSLQVKPLQVEPPEPVVAVALGASRQLTCRLACADRGAS
VQWRGLDTSLGAVQSDTGRSVLTVRNASLSAAGTRVCVG
SCGGRTFQHTVQLLVYAFPDQLTVSPAALVPGDPEVACT
AHKVTPVDPNALSFSLLVGGQELEGAQALGPEVQEEEEE
PQGDEDVLFRVTERWRLPPLGTPVPPALYCQATMRLPGL
ELSHRQAIPVLHSPTSPEPPDTTSPESPDTTSPESPDTT
SQEPPDTTSPEPPDKTSPEPAPQQGSTHTPRSPGSTRTR
RPEISQAGPTQGEVIPTGSSKPAGDQ

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

other info2 :

Species: Homo sapiens (Human)

products categories :

Immunology

products description :

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

products references :

Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts." Leung E., Greene J., Ni J., Raymond L.G., Lehnert K., Langley R., Krissansen G.W. Immunol. Cell Biol. 74:490-496(1996)

ncbi gi num :

109633022

ncbi acc num :

NP_570116.2

ncbi gb acc num :

NM_130760.2

uniprot acc num :

Q13477

ncbi mol weight :

47.39kD

ncbi pathways :

Adaptive Immune System Pathway (1269171); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Extracellular Matrix Organization Pathway (1270244); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Integrin Cell Surface Interactions Pathway (1270260); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Paxillin-independent Events Mediated By A4b1 And A4b7 Pathway (137971)

ncbi summary :

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

MADCAM1: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: integral to membrane; membrane; plasma membrane. Biological Process: aging; cell adhesion; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; immune response; integrin-mediated signaling pathway; keratinocyte differentiation; leukocyte tethering or rolling; positive regulation of leukocyte migration; receptor clustering; regulation of immune response; signal transduction

size1 :

0.05 mg (E-Coli)

price1 :

180 USD

size2 :

0.2 mg (E-Coli)

price2 :

490

size3 :

0.5 mg (E-Coli)

price3 :

715

size4 :

0.05 mg (Baculovirus)

price4 :

950

size5 :

1 mg (E-Coli)

price5 :

1170

more info or order :

MyBioSource product webpage