catalog number :
MBS128112
products full name :
MAPKBP1 Polyclonal Antibody
products short name :
MAPKBP1
products name syn :
JNKBP-1; MGC138851; MGC138852
other names :
Mitogen-activated protein kinase-binding protein 1; Mitogen-activated protein kinase-binding protein 1; mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1; mitogen activated protein kinase binding protein 1; mitogen-activated protein kinase binding protein 1; JNK-binding protein 1; JNKBP-1
products gene name :
MAPKBP1
other gene names :
MAPKBP1; MAPKBP1; JNKBP-1; JNKBP1; KIAA0596; JNKBP-1
uniprot entry name :
MABP1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Affinity Purification
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:200 - 1:500. IHC: 1:50 - 1:100. IF: 1:20 - 1:50
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Immunogen: Fusion protein of human MAPKBP1. Calculated Molecular Weight: 109kDa; 164kDa
products categories :
Polyclonal
products description :
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
uniprot summary :
MAPKBP1: Involved in JNK signaling pathway. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 15q15.1