FSHR Polyclonal Antibody | MyBioSource MBS128093 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FSHR Polyclonal Antibody

catalog :

MBS128093

quantity :

0.05 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS128093

products type :

Antibody

products full name :

FSHR Polyclonal Antibody

products short name :

FSHR

products name syn :

FSHR; FSHRO; LGR1; MGC141667; MGC141668; ODG1

other names :

Follicle-stimulating hormone receptor; Follicle-stimulating hormone receptor; follicle-stimulating hormone receptor; FSH receptor; follitropin receptor; follicle stimulating hormone receptor; Follitropin receptor

products gene name :

FSHR

other gene names :

FSHR; FSHR; LGR1; ODG1; FSHRO; LGR1; FSH-R

uniprot entry name :

FSHR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

695

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200

other info1 :

Species: Human. Immunogen: Recombinant Protein

other info2 :

Immunogen: Recombinant protein of human FSHR. Calculated Molecular Weight: 78kDa

products categories :

Polyclonal

products description :

FSHR, also named as LGR1, belongs to the G-protein coupled receptor 1 family and FSH/LSH/TSH subfamily. FSHR is a receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). The antibody is special to FSHR.

ncbi gi num :

311033420

ncbi acc num :

P23945.3

uniprot acc num :

P23945

ncbi mol weight :

695

ncbi pathways :

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); FSH Signaling Pathway (672455); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); GPCRs, Other Pathway (198765); Hormone Ligand-binding Receptors Pathway (106369)

ncbi summary :

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

uniprot summary :

FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p21-p16. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; follicle-stimulating hormone receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; gonad development; follicle-stimulating hormone signaling pathway; male gonad development; female gamete generation; spermatogenesis; female gonad development. Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1

size1 :

0.05 mL

price1 :

230 USD

size2 :

0.1 mL

price2 :

305

size3 :

0.2 mL

price3 :

460

more info or order :

MyBioSource product webpage