product summary
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company name :
MyBioSource
product type :
antibody
product name :
TFAM Polyclonal Antibody
catalog :
MBS128046
quantity :
0.05 mL
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS128046
products type :
Antibody
products full name :
TFAM Polyclonal Antibody
products short name :
TFAM
products name syn :
TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3
other names :
Transcription factor A, mitochondrial; Transcription factor A, mitochondrial; transcription factor A, mitochondrial; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor); transcription factor A, mitochondrial; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2
products gene name :
TFAM
other gene names :
TFAM; TFAM; TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; TCF6; TCF6L2; mtTFA; MtTF1; TCF-6
uniprot entry name :
TFAM_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
246
purity :
Affinity Purification
concentration :
1mg/ml
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Immunogen: Recombinant protein of human TFAM. Calculated Molecular Weight: 29kDa
products categories :
Polyclonal
products description :
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
ncbi gi num :
417324
ncbi acc num :
Q00059.1
uniprot acc num :
Q00059
ncbi mol weight :
246
ncbi pathways :
Energy Metabolism Pathway (198907); Gene Expression Pathway (105937); Huntington's Disease Pathway (83100); Huntington's Disease Pathway (512); Mitochondrial Gene Expression Pathway (198757); Mitochondrial Biogenesis Pathway (1127495); Mitochondrial Transcription Initiation Pathway (106569); Organelle Biogenesis And Maintenance Pathway (1127494); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); Transcription From Mitochondrial Promoters Pathway (106568)
ncbi summary :
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
uniprot summary :
TFAM: regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. Protein type: Transcription regulation; DNA-binding. Chromosomal Location of Human Ortholog: 10q21. Cellular Component: mitochondrion; mitochondrial matrix; nucleus; cytosol. Molecular Function: protein binding; heat shock protein binding; chromatin binding; transcription factor activity; DNA bending activity. Biological Process: mitochondrial respiratory chain complex assembly; chromatin remodeling; mitochondrion organization and biogenesis; regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter
size1 :
0.05 mL
price1 :
230 USD
size2 :
0.1 mL
price2 :
305
size3 :
0.2 mL
price3 :
460
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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