P2RX7 cDNA Clone | MyBioSource MBS1278499 product information

product summary

company name :

MyBioSource

product type :

cDNA

product name :

P2RX7 cDNA Clone

catalog :

MBS1278499

quantity :

0.01 mg Plasmid + 0.

price :

525 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1278499

products type :

cDNA Clone

products full name :

P2RX7 cDNA Clone

products short name :

P2RX7

other names :

Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 7, mRNA; P2X purinoceptor 7; P2X purinoceptor 7; purinergic receptor P2X 7; ATP receptor; P2Z receptor; Purinergic receptor

products gene name :

P2RX7

other gene names :

P2RX7; P2RX7; P2X7; P2X7

uniprot entry name :

P2RX7_HUMAN

sequence length :

2155

sequence :

atgccggcctgctgcagctgcagtgatgttttccagtat
gagacgaacaaagtcactcggatccagagcatgaattat
ggcaccattaagtggttcttccacgtgatcatcttttcc
tacgtttgctttgctctggtgagtgacaagctgtaccag
cggaaagagcctgtcatcagttctgtgcacaccaaggtg
aaggggatagcagaggtgaaagaggagatcgtggagaat
ggagtgaagaagttggtgcacagtgtctttgacaccgca
gactacaccttccctttgcaggggaactctttcttcgtg
atgacaaactttctcaaaacagaaggccaagagcagcgg
ttgtgtcccgagtatcccacccgcaggacgctctgttcc
tctgaccgaggttgtaaaaagggatggatggacccgcag
agcaaaggaattcagaccggaaggtgtgtagtgcatgaa
gggaaccagaagacctgtgaagtctctgcctggtgcccc
atcgaggcagtggaagaggccccccggcctgctctcttg
aacagtgccgaaaacttcactgtgctcatcaagaacaat
atcgacttccccggccacaactacaccacgagaaacatc
ctgccaggtttaaacatcacttgtaccttccacaagact
cagaatccacagtgtcccattttccgactaggagacatc
ttccgagaaacaggcgataatttttcagatgtggcaatt
cagggcggaataatgggcattgagatctactgggactgc
aacctagaccgttggttccatcactgccatcccaaatac
agtttccgtcgccttgacgacaagaccaccaacgtgtcc
ttgtaccctggctacaacttcagatacgccaagtactac
aaggaaaacaatgttgagaaacggactctgataaaagtc
ttcgggatccgttttgacatcctggtttttggcaccgga
ggaaaatttgacattatccagctggttgtgtacatcggc
tcaaccctctcctacttcggtctggccgctgtgttcatc
gacttcctcatcgacacttactccagtaactgctgtcgc
tcccatatttatccctggtgcaagtgctgtcagccctgt
gtggtcaacgaatactactacaggaagaagtgcgagtcc
attgtggagccaaagccgacattaaagtatgtgtccttt
gtggatgaatcccacattaggatggtgaaccagcagcta
ctagggagaagtctgcaagatgtcaagggccaagaagtc
ccaagacctgcgatggacttcacagatttgtccaggctg
cccctggccctccatgacacacccccgattcctggacaa
ccagaggagatacagctgcttagaaaggaggcgactcct
agatccagggatagccccgtctggtgccagtgtggaagc
tgcctcccatctcaactccctgagagccacaggtgcctg
gaggagctgtgctgccggaaaaagccgggggcctgcatc
accacctcagagctgttcaggaagctggtcctgtccaga
cacgtcctgcagttcctcctgctctaccaggagcccttg
ctggcgctggatgtggattccaccaacagccggctgcgg
cactgtgcctacaggtgctacgccacctggcgcttcggc
tcccaggacatggctgactttgccatcctgcccagctgc
tgccgctggaggatccggaaagagtttccgaagagtgaa
gggcagtacagtggcttcaagagtccttactga

other info1 :

Vector: Please Inquire

ncbi gi num :

33877741

ncbi acc num :

BC011913

ncbi mol weight :

58,239 Da

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Immune System Pathway (106386); Inflammasomes Pathway (366166); Innate Immune System Pathway (106387); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways (366164); The NLRP3 Inflammasome Pathway (366167)

ncbi summary :

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

uniprot summary :

P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation. Protein type: Receptor, misc.; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 12q24. Cellular Component: cytoplasm; integral to nuclear inner membrane; integral to plasma membrane; membrane; plasma membrane. Molecular Function: ATP binding; ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; purinergic nucleotide receptor activity; receptor binding. Biological Process: bleb formation; blood coagulation; cell surface receptor linked signal transduction; membrane depolarization; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phospholipid scrambling; pore complex biogenesis; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization and biogenesis; positive regulation of glycolysis; positive regulation of interleukin-1 beta secretion; regulation of sodium ion transport; response to ATP; sensory perception of pain. Disease: Leukemia, Chronic Lymphocytic

size1 :

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

price1 :

525 USD

more info or order :

MyBioSource product webpage