product summary
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company name :
MyBioSource
product type :
cDNA
product name :
TNFRSF1B cDNA Clone
catalog :
MBS1278225
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1278225
products type :
cDNA Clone
products full name :
TNFRSF1B cDNA Clone
products short name :
TNFRSF1B
other names :
Homo sapiens tumor necrosis factor receptor superfamily, member 1B, mRNA; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily member 1B; TNF receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2
products gene name :
TNFRSF1B
other gene names :
TNFRSF1B; TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II
uniprot entry name :
TNR1B_HUMAN
sequence length :
3692
sequence :
atggcgcccgtcgccgtctgggccgcgctggccgtcgga
ctggagctctgggctgcggcgcacgccttgcccgcccag
gtggcatttacaccctacgccccggagcccgggagcaca
tgccggctcagagaatactatgaccagacagctcagatg
tgctgcagcaaatgctcgccgggccaacatgcaaaagtc
ttctgtaccaagacctcggacaccgtgtgtgactcctgt
gaggacagcacatacacccagctctggaactgggttccc
gagtgcttgagctgtggctcccgctgtagctctgaccag
gtggaaactcaagcctgcactcgggaacagaaccgcatc
tgcacctgcaggcccggctggtactgcgcgctgagcaag
caggaggggtgccggctgtgcgcgccgctgcgcaagtgc
cgcccgggcttcggcgtggccagaccaggaactgaaaca
tcagacgtggtgtgcaagccctgtgccccggggacgttc
tccaacacgacttcatccacggatatttgcaggccccac
cagatctgtaacgtggtggccatccctgggaatgcaagc
atggatgcagtctgcacgtccacgtcccccacccggagt
atggccccaggggcagtacacttaccccagccagtgtcc
acacgatcccaacacacgcagccaactccagaacccagc
actgctccaagcacctccttcctgctcccaatgggcccc
agccccccagctgaagggagcactggcgacttcgctctt
ccagttggactgattgtgggtgtgacagccttgggtcta
ctaataataggagtggtgaactgtgtcatcatgacccag
gtgaaaaagaagcccttgtgcctgcagagagaagccaag
gtgcctcacttgcctgccgataaggcccggggtacacag
ggccccgagcagcagcacctgctgatcacagcgccgagc
tccagcagcagctccctggagagctcggccagtgcgttg
gacagaagggcgcccactcggaaccagccacaggcacca
ggcgtggaggccagtggggccggggaggcccgggccagc
accgggagctcagattcttcccctggtggccatgggacc
caggtcaatgtcacctgcatcgtgaacgtctgtagcagc
tctgaccacagctcacagtgctcctcccaagccagctcc
acaatgggagacacagattccagcccctcggagtccccg
aaggacgagcaggtccccttctccaaggaggaatgtgcc
tttcggtcacagctggagacgccagagaccctgctgggg
agcaccgaagagaagcccctgccccttggagtgcctgat
gctgggatgaagcccagttaa
other info1 :
Vector: Please Inquire
ncbi gi num :
31419789
ncbi acc num :
BC052977
ncbi mol weight :
28,461 Da
ncbi pathways :
Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL-3 Signaling Pathway (198881); Inflammatory Response Pathway (198766)
ncbi summary :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
uniprot summary :
TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: integral to plasma membrane; lipid raft; plasma membrane. Molecular Function: protein binding; ubiquitin protein ligase binding. Biological Process: immune response; inflammatory response; multicellular organismal development; positive regulation of MAPKKK cascade; positive regulation of membrane protein ectodomain proteolysis; regulation of apoptosis; regulation of cell proliferation; tumor necrosis factor-mediated signaling pathway
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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