AKAP9 cDNA Clone | MyBioSource MBS1277122 product information

product summary

company name :

MyBioSource

product type :

cDNA

product name :

AKAP9 cDNA Clone

catalog :

MBS1277122

quantity :

0.01 mg Plasmid + 0.

price :

165 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1277122

products type :

cDNA Clone

products full name :

AKAP9 cDNA Clone

products short name :

AKAP9

other names :

Homo sapiens A kinase (PRKA) anchor protein (yotiao) 9, mRNA; A-kinase anchor protein 9; A-kinase anchor protein 9; A-kinase anchoring protein 9; A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein

products gene name :

AKAP9

other gene names :

AKAP9; AKAP9; LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16A; AKAP350; AKAP450; KIAA0803; PRKA9

uniprot entry name :

AKAP9_HUMAN

sequence length :

1370

sequence :

atggaggacgaggagagacagaagaagctggaggccggc
aaagccaagcttgcccagtttcgacaaagaaaagctcag
tcggatgggcagagtccttccaagaagcagaaaaaaaag
agaaaaacgtcaagcagtaaacatgatgtgtcagcacac
catgatttgaatattgatcaatcacagtgtaatgaaatg
tacataaatagttctcagagagtagaatcaactgtgatt
cctgaatctacaataatgagaactctacatagtggagaa
ataaccagtcatgagcagggcttctctgtggaactggaa
agtgaaatttcaaccacagcagatgactgcagttcagag
gtaaatggttgcagttttgtgatgagaacaggaaagcct
acaaatttattaagggaagaagaatttggtgttgatgat
tcttattctgaacaaggagcacaagacagtccgactcat
ctagagatgatggaaagtgagttggctgggaagcagcat
gagattgaagagctaaacagagagctggaagaaatgagg
gttacctatgggactgaaggactgcagcagttacaagaa
tttgaagctgccattaaacaaagagatggcattataacc
cagctcactgctaatttacaacaagcaagaagagaaaag
gatgagacaatgagagaatttttagagttgacagaacag
agtcaaaaattacagattcaatttcagcaattacaggct
agtgaaactctgagaaacagcactcatagtagcacagct
gcagacttactacaagccaaacaacagatcctcactcat
caacagcagcttgaagaacaagaccacttattagaagat
tatcagaaaaagaaagaagacttcacaatgcaaattagt
ttcttgcaagagaaaattaaagtatatgaaatggtatgt
ttattttaa

other info1 :

Vector: Please Inquire

ncbi gi num :

34190434

ncbi acc num :

BC015533

ncbi mol weight :

455,423 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Centrosome Maturation Pathway (105807); G Protein Signaling Pathways (198849); G2/M Transition Pathway (105801); Loss Of Nlp From Mitotic Centrosomes Pathway (105811); Loss Of Proteins Required For Interphase Microtubule OrganizationÃ‚Â From The Centrosome Pathway (105810)

ncbi summary :

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]

uniprot summary :

AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7q21-q22. Cellular Component: centrosome; cis-Golgi network; cytoskeleton; cytosol; Golgi apparatus; Golgi stack; intracellular membrane-bound organelle; voltage-gated potassium channel complex. Molecular Function: potassium channel regulator activity; protein binding; protein complex scaffold; Ras guanyl-nucleotide exchange factor activity; receptor binding. Biological Process: G2/M transition of mitotic cell cycle; MAPKKK cascade; microtubule nucleation; positive regulation of peptidyl-serine phosphorylation; signal transduction; synaptic transmission; transport. Disease: Long Qt Syndrome 11

size1 :

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

price1 :

165 USD

more info or order :

MyBioSource product webpage