cDNA

GABARAPL2 cDNA Clone

MBS1277093

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

165 USD

cDNA Clone

GABARAPL2 cDNA Clone

[GABARAPL2]

[Homo sapiens GABA(A) receptor-associated protein-like 2, mRNA; Gamma-aminobutyric acid receptor-associated protein-like 2; gamma-aminobutyric acid receptor-associated protein-like 2; ganglioside expression factor 2; MAP1 light chain 3 related protein; MAP1 light chain 3-related protein; general protein transport factor p16; golgi-associated ATPase enhancer of 16 kDa; GABA(A) receptor-associated protein-like 2; GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; GEF-2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; GATE-16; MAP1 light chain 3-related protein]

[GABARAPL2]

[GABARAPL2; GABARAPL2; ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16; FLC3A; GEF2; GEF-2; GATE-16]

GBRL2_HUMAN

354

atgaagtggatgttcaaggaggaccactcgctggaacac
agatgcgtggagtccgcgaagattcgagcgaaatatccc
gacagggttccggtgattgtggaaaaggtctcaggctct
cagattgttgacattgacaaacggaagtacttggtccca
tctgatatcactgtggctcagttcatgtggatcatcagg
aaaaggatccagcttccttctgaaaaggcgatcttcctg
tttgtggataagacagtcccacagtccagcctaactatg
ggacagctttacgagaaggaaaaagatgaagatggattc
ttatatgtggcctacagcggagagaacacttttggcttc
tga

Vector: pENTR223.1

Clone Sequence Report: Provided with product shipment

20809933

BC029601

P60520

GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468); Senescence And Autophagy Pathway (198780)

GABARAPL2: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. Implicated in intra-Golgi transport and post-mitotic Golgi re-assembly. Modulates the activity of SNAREs in the Golgi apparatus and is therefore an essential component of intra-Golgi transport and post-mitotic Golgi re-assembly. It first stimulates the ATPase activity of NSF, which in turn stimulates the association with GOSR1. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin. Interacts with ULK1. Phosphorylated upon DNA damage, probably by ATM or ATR. Protein type: Autophagy; Adaptor/scaffold; Ubiquitin-like modifier; Vesicle; Microtubule-binding. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: Golgi membrane; Golgi apparatus; extrinsic to membrane; cytoplasm; autophagic vacuole; cytoplasmic vesicle; intracellular; cytosol. Molecular Function: protein binding; SNARE binding; microtubule binding; beta-tubulin binding; GABA receptor binding; ATPase binding. Biological Process: intra-Golgi vesicle-mediated transport; protein transport; positive regulation of ATPase activity; mitochondrion degradation; autophagy; cellular response to nitrogen starvation; autophagic vacuole formation

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

165 USD