CYP1A1 Polyclonal Antibody | MyBioSource MBS127670 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CYP1A1 Polyclonal Antibody

catalog :

MBS127670

quantity :

0.05 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS127670

products type :

Antibody

products full name :

CYP1A1 Polyclonal Antibody

products short name :

CYP1A1

products name syn :

AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX

other names :

Cytochrome P450 1A1; Cytochrome P450 1A1; cytochrome P450 1A1; CYPIA1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; cytochrome P450, family 1, subfamily A, polypeptide 1; CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1

products gene name :

CYP1A1

other gene names :

CYP1A1; CYP1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX

uniprot entry name :

CP1A1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

512

purity :

Affinity Purification

storage stability :

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200

other info1 :

Species: Human. Immunogen: Recombinant Protein of human CYP1A1. Category: Primary Antibodies

products categories :

Polyclonal

products description :

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

ncbi gi num :

117139

ncbi acc num :

P04798.1

uniprot acc num :

P04798

ncbi mol weight :

58kDa

ncbi pathways :

AhR Pathway (755436); Arachidonic Acid Metabolism Pathway (685553); Benzo(a)pyrene Metabolism Pathway (198911); Biological Oxidations Pathway (105698); Chemical Carcinogenesis Pathway (673221); Chemical Carcinogenesis Pathway (673237); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway (1127640); Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway (1127641); Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway (1127642)

ncbi summary :

uniprot summary :

CYP1A1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family. Protein type: Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450. Chromosomal Location of Human Ortholog: 15q24.1. Cellular Component: endoplasmic reticulum membrane; mitochondrion. Molecular Function: oxidoreductase activity, acting on diphenols and related substances as donors; flavonoid 3 -monooxygenase activity; enzyme binding; iron ion binding; heme binding; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; demethylase activity. Biological Process: coumarin metabolic process; response to nematode; response to arsenic; response to lipopolysaccharide; cellular lipid metabolic process; response to vitamin A; response to antibiotic; embryonic development ending in birth or egg hatching; flavonoid metabolic process; porphyrin metabolic process; response to wounding; arachidonic acid metabolic process; drug metabolic process; aging; response to food; response to drug; insecticide metabolic process; camera-type eye development; response to iron(III) ion; response to virus; epoxygenase P450 pathway; response to herbicide; dibenzo-p-dioxin catabolic process; vitamin D metabolic process; cell proliferation; response to hyperoxia; gut development; xenobiotic metabolic process; maternal process involved in parturition; response to hypoxia; 9-cis-retinoic acid biosynthetic process; amine metabolic process; hydrogen peroxide biosynthetic process

size1 :

0.05 mL

price1 :

230 USD

size2 :

0.1 mL

price2 :

305

size3 :

0.2 mL

price3 :

460

more info or order :

MyBioSource product webpage