cDNA

RPL11 cDNA Clone

MBS1276408

0.01 mg Plasmid + 0.

165 USD

cDNA Clone

RPL11 cDNA Clone

RPL11

Homo sapiens ribosomal protein L11, mRNA; 60S ribosomal protein L11; 60S ribosomal protein L11; ribosomal protein L11; CLL-associated antigen KW-12

RPL11

RPL11; RPL11; L11; DBA7; GIG34

RL11_HUMAN

611

atggcggatcaaggtgaaaaggagaaccccatgcgggaa
cttcgcatccgcaaactctgtctcaacatctgtgttggg
gagagtggagacagactgacgcgagcagccaaggtgttg
gagcagctcacagggcagacccctgtgttttccaaagct
agatacactgtcagatcctttggcatccggagaaatgaa
aagattgctgtccactgcacagttcgaggggccaaggca
gaagaaatcttggagaagggtctaaaggtgcgggagtat
gagttaagaaaaaacaacttctcagatactggaaacttt
ggttttgggatccaggaacacatcgatctgggtatcaaa
tatgacccaagcattggtatctacggcctggacttctat
gtggtgctgggtaggccaggtttcagcatcgcagacaag
aagcgcaggacaggctgcattggggccaaacacagaatc
agcaaagaggaggccatgcgctggttccagcagaagtat
gatgggatcatccttcctggcaaataa

Vector: Please Inquire

40226081

BC018970

20,124 Da

Cap-dependent Translation Initiation Pathway (105967); Cytoplasmic Ribosomal Proteins Pathway (198853); Disease Pathway (530764); Eukaryotic Translation Elongation Pathway (105976); Eukaryotic Translation Initiation Pathway (105966); Eukaryotic Translation Termination Pathway (105978); Formation Of A Pool Of Free 40S Subunits Pathway (105968); GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway (105973); Gene Expression Pathway (105937); Influenza Infection Pathway (106067)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]

RPL11: Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML. Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7). DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L5P family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation. Chromosomal Location of Human Ortholog: 1p36.1-p35. Cellular Component: cytoplasm; cytosol; extracellular matrix; membrane; nucleolus. Molecular Function: protein binding; RNA binding. Biological Process: mRNA catabolic process, nonsense-mediated decay; protein targeting; ribosomal large subunit assembly and maintenance; ribosomal large subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translational initiation; viral transcription. Disease: Diamond-blackfan Anemia 7

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

165 USD