catalog number :
MBS1276377
products type :
cDNA Clone
products full name :
ANXA2 cDNA Clone
products short name :
ANXA2
other names :
Homo sapiens annexin A2, mRNA; Annexin A2; annexin A2; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; calpactin I heavy polypeptide; placental anticoagulant protein IV; annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
products gene name :
ANXA2
other gene names :
ANXA2; ANXA2; P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV
uniprot entry name :
ANXA2_HUMAN
sequence :
TGAATTCAAGAGAAAGTACGGCAAGTCCCTGTACTATTATATCCAGCAAGACACTAA GGGCGACTACCAGAAAGCGCTGCTGTACCTGTGTGGTGGAGATGACTGA
ATGTCTACTGTTCACGAAATCCTGTGCAAGCTCAGCTTG
GAGGGTGATCACTCTACACCCCCAAGTGCATATGGGTCT
GTCAAAGCCTATACTAACTTTGATGCTGAGCGGGATGCT
TTGAACATTGAAACAGCCATCAAGACCAAAGGTGTGGAT
GAGGTCACCATTGTCAACATTTTGACCAACCGCAGCAAT
GCACAGAGACAGGATATTGCCTTCGCCTACCAGAGAAGG
ACCAAAAAGGAACTTGCATCAGCACTGAAGTCAGCCTTA
TCTGGCCACCTGGAGACGTTGATTTTGGGCCTATTGAAG
ACACCTGCTCAGTATGACGCTTCTGAGCTAAAAGCTTCC
ATGAAGGGGCTGGGAACCGACGAGGACTCTCTCATTGAG
ATCATCTGCTCCAGAACCAACCAGGAGCTGCAGGAAATT
AACAGAGTCTACAAGGAAATGTACAAGACTGATCTGGAG
AAGGACATTATTTCGGACACATCTGGTGACTTCCGCAAG
CTGATGGTTGCCCTGGCAAAGGGTAGAAGAGCAGAGGAT
GGCTCTGTCATTGATTATGAACTGATTGACCAAGATGCT
CGGGATCTCTATGACGCTGGAGTGAAGAGGAAAGGAACT
GATGTTCCCAAGTGGATCAGCATCATGACCGAGCGGAGC
GTGCCCCACCTCCAGAAAGTATTTGATAGGTACAAGAGT
TACAGCCCTTATGACATGTTGGAAAGCATCAGGAAAGAG
GTTAAAGGAGACCTGGAAAATGCTTTCCTGAACCTGGTT
CAGTGCATTCAGAACAAGCCCCTGTATTTTGCTGATCGG
CTGTATGACTCCATGAAGGGCAAGGGGACGCGAGATAAG
GTCCTGATCAGAATCATGGTCTCCCGCAGTGAAGTGGAC
ATGTTGAAAATTAGGTC
other info1 :
cDNA Size: 1020. Insert site: rrnB_T1, rrnB_T2. GeneID: 302. Vector: Please Inquire
products description :
Homo sapiens annexin A2, mRNA (cDNA clone MGC:10129 IMAGE:3901641),complete cds.
ncbi mol weight :
38,604 Da
ncbi pathways :
Prostaglandin Synthesis And Regulation Pathway (198912)
ncbi summary :
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. Protein type: Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 15q22.2. Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; protein complex; late endosome membrane; lysosomal membrane; early endosome; lipid particle; cell cortex; lipid raft; ruffle; extracellular matrix; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; basement membrane; midbody; nucleus; endosome; vesicle; sarcolemma. Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; calcium-dependent protein binding; Rab GTPase binding. Biological Process: fibrinolysis; positive regulation of fibroblast proliferation; collagen fibril organization; negative regulation of catalytic activity; protein heterotetramerization; positive regulation of vesicle fusion; angiogenesis; positive regulation of protein amino acid phosphorylation; positive regulation of binding; lipid raft formation; body fluid secretion; membrane budding
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock