product summary
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company name :
MyBioSource
product type :
cDNA
product name :
HLA-DMB cDNA Clone
catalog :
MBS1276367
quantity :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1276367
products type :
cDNA Clone
products full name :
HLA-DMB cDNA Clone
products short name :
[HLA-DMB]
other names :
[Homo sapiens major histocompatibility complex, class II, DM beta, mRNA; HLA class II histocompatibility antigen, DM beta chain; HLA class II histocompatibility antigen, DM beta chain; major histocompatibility complex, class II, DM beta; MHC class II antigen DMB; Really interesting new gene 7 protein]
products gene name :
[HLA-DMB]
other gene names :
[HLA-DMB; HLA-DMB; RING7; D6S221E; DMB; RING7]
uniprot entry name :
DMB_HUMAN
sequence length :
792
sequence :
atgatcacattcctgccgctgctgctggggctcagcctg
ggctgcacaggagcaggtggcttcgtggcccatgtggaa
agcacctgtctgttggatgatgctgggactccaaaggat
ttcacatactgcatctccttcaacaaggatctgctgacc
tgctgggatccagaggagaataagatggccccttgcgaa
tttggggtgctgaatagcttggcgaatgtcctctcacag
cacctcaaccaaaaagacaccctgatgcagcgcttgcgc
aatgggcttcagaattgtgccacacacacccagcccttc
tggggatcactgaccaacaggacacggccaccatctgtg
caagtagccaaaaccactccttttaacacgagggagcct
gtgatgctggcctgctatgtgtggggcttctatccagca
gaagtgactatcacgtggaggaagaacgggaagcttgtc
atgcctcacagcagtgcgcacaagactgcccagcccaat
ggagactggacataccagaccctctcccatttagcctta
accccctcttacggggacacttacacctgtgtggtagag
cacattggggctcctgagcccatccttcgggactggaca
cctgggctgtcccccatgcagaccctgaaggtttctgtg
tctgcagtgactctgggcctgggcctcatcatcttctct
cttggtgtgatcagctggcggagagctggccactctagt
tacactcctcttcctgggtccaattattcagaaggatgg
cacatttcctag
other info1 :
Vector: pENTR223.1
other info2 :
Clone Sequence Report: Provided with product shipment
ncbi gi num :
20073044
ncbi acc num :
BC027175
ncbi mol weight :
28,943 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Cell Adhesion Molecules (CAMs) Pathway (83069)
ncbi summary :
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
uniprot summary :
HLA-DMB: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Belongs to the MHC class II family. Protein type: Vesicle; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: lysosomal membrane; MHC class II protein complex. Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; MHC class II protein complex assembly; peptide antigen assembly with MHC class II protein complex; positive regulation of T cell proliferation
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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