product summary
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company name :
MyBioSource
product type :
cDNA
product name :
HLA-DMA cDNA Clone
catalog :
MBS1276029
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
product information
catalog number :
MBS1276029
products type :
cDNA Clone
products full name :
HLA-DMA cDNA Clone
products short name :
HLA-DMA
other names :
Homo sapiens major histocompatibility complex, class II, DM alpha, mRNA; HLA class II histocompatibility antigen, DM alpha chain; HLA class II histocompatibility antigen, DM alpha chain; major histocompatibility complex, class II, DM alpha; MHC class II antigen DMA; Really interesting new gene 6 protein
products gene name :
HLA-DMA
other gene names :
HLA-DMA; HLA-DMA; DMA; HLADM; RING6; D6S222E; DMA; RING6
uniprot entry name :
DMA_HUMAN
sequence length :
1123
sequence :
atgggtcatgaacagaaccaaggagctgcgctgctacag
atgttaccacttctgtggctgctaccccactcctgggcc
gtccctgaagctcctactccaatgtggccagatgacctg
caaaaccacacattcctgcacacagtgtactgccaggat
gggagtcccagtgtgggactctctgaggcctacgacgag
gaccagcttttcttcttcgacttttcccagaacactcgg
gtgcctcgcctgcccgaatttgctgactgggctcaggaa
cagggagatgctcctgccattttatttgacaaagagttc
tgcgagtggatgatccagcaaatagggccaaaacttgat
gggaaaatcccggtgtccagagggtttcctatcgctgaa
gtgttcacgctgaagcccctggagtttggcaagcccaac
actttggtctgttttgtcagtaatctcttcccacccatg
ctgacagtgaactggcagcatcattccgtccctgtggaa
ggatttgggcctacttttgtctcagctgtcgatggactc
agcttccaggccttttcttacttaaacttcacaccagaa
ccttctgacattttctcctgcattgtgactcacgaaatt
gaccgctacacagcaattgcctattgggtaccccggaac
gcactgccctcagatctgctggagaatgtgctgtgtggc
gtggcctttggcctgggtgtgctgggcatcatcgtgggc
attgttctcatcatctacttccggaagccttgctcaggt
gactga
atgttaccacttctgtggctgctaccccactcctgggcc
gtccctgaagctcctactccaatgtggccagatgacctg
caaaaccacacattcctgcacacagtgtactgccaggat
gggagtcccagtgtgggactctctgaggcctacgacgag
gaccagcttttcttcttcgacttttcccagaacactcgg
gtgcctcgcctgcccgaatttgctgactgggctcaggaa
cagggagatgctcctgccattttatttgacaaagagttc
tgcgagtggatgatccagcaaatagggccaaaacttgat
gggaaaatcccggtgtccagagggtttcctatcgctgaa
gtgttcacgctgaagcccctggagtttggcaagcccaac
actttggtctgttttgtcagtaatctcttcccacccatg
ctgacagtgaactggcagcatcattccgtccctgtggaa
ggatttgggcctacttttgtctcagctgtcgatggactc
agcttccaggccttttcttacttaaacttcacaccagaa
ccttctgacattttctcctgcattgtgactcacgaaatt
gaccgctacacagcaattgcctattgggtaccccggaac
gcactgccctcagatctgctggagaatgtgctgtgtggc
gtggcctttggcctgggtgtgctgggcatcatcgtgggc
attgttctcatcatctacttccggaagccttgctcaggt
gactga
other info1 :
Vector: Please Inquire
ncbi gi num :
15030335
ncbi acc num :
BC011447
ncbi mol weight :
29,194 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Cell Adhesion Molecules (CAMs) Pathway (83069)
ncbi summary :
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]
uniprot summary :
HLA-DMA: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Belongs to the MHC class II family. Protein type: Membrane protein, integral; Chaperone. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cell surface; lysosomal membrane; membrane; MHC class II protein complex. Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
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