antibody

WWP2 Polyclonal Antibody

MBS127581

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

Antibody

WWP2 Polyclonal Antibody

[WWP2]

[WWP2; AIP2; WWp2-like; NEDD4-like E3 ubiquitin-protein ligase WWP2]

[NEDD4-like E3 ubiquitin-protein ligase WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2; atrophin-1 interacting protein 2; WW domain containing E3 ubiquitin protein ligase 2; Atrophin-1-interacting protein 2; AIP2; WW domain-containing protein 2]

[WWP2]

[WWP2; WWP2; AIP2; WWp2-like; AIP2]

WWP2_HUMAN

Polyclonal

IgG

Rabbit

Human

870

Affinity Purification

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

Recommended Dilutions: WB 1:500 - 1:2000

Western Blot (WB)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 151-400 of human WWP2 (NP_001257383.1).

Polyclonal

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.

32171765

O00308.2

O00308

Observed MW 105kDa. Calculated MW 35kDa/51kDa/86kDa/98kDa

Ubiquitin Mediated Proteolysis Pathway (83056); Ubiquitin Mediated Proteolysis Pathway (466)

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

WWP2: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by Lys-63 -linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Ligase; EC 6.3.2.19; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: membrane; cytoplasm; nucleus; ubiquitin ligase complex. Molecular Function: protein binding; ubiquitin-protein ligase activity; transcription factor binding; ligase activity. Biological Process: proteasomal ubiquitin-dependent protein catabolic process; entry of virus into host cell; regulation of membrane potential; protein autoubiquitination; negative regulation of transcription factor activity; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination; protein modification process; negative regulation of protein transport; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transporter activity

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430