SCNN1G cDNA Clone | MyBioSource MBS1275625 product information

product summary

company name :

MyBioSource

product type :

cDNA

product name :

SCNN1G cDNA Clone

catalog :

MBS1275625

quantity :

0.01 mg Plasmid + 0.

price :

165 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1275625

products type :

cDNA Clone

products full name :

SCNN1G cDNA Clone

products short name :

SCNN1G

other names :

Homo sapiens sodium channel, nonvoltage-gated 1, gamma, mRNA; Amiloride-sensitive sodium channel subunit gamma; amiloride-sensitive sodium channel subunit gamma; sodium channel epithelial 1 gamma subunit; Epithelial Na(+) channel subunit gamma; ENaCG; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG

products gene name :

SCNN1G

other gene names :

SCNN1G; SCNN1G; PHA1; BESC3; ENaCg; SCNEG; ENaCgamma; ENaCG; Gamma-ENaC

uniprot entry name :

SCNNG_HUMAN

sequence length :

3516

sequence :

atggcacccggagagaagatcaaagccaaaatcaagaag
aatctgcccgtgacgggccctcaggcgccgaccattaaa
gagctgatgcggtggtactgcctcaacaccaacacccat
ggctgtcgccgcatcgtggtgtcccgcggccgtctgcgc
cgcctcctctggatcgggttcacactgactgccgtggcc
ctcatcctctggcagtgcgccctcctcgtcttctccttc
tatactgtctcagtttccatcaaagtccacttccggaag
ctggattttcctgcagtcaccatctgcaacatcaacccc
tacaagtacagcaccgttcgccaccttctagctgacttg
gaacaggagaccagagaggccctgaagtccctgtatggc
tttccagagtcccggaagcgccgagaggcggagtcctgg
aactccgtctcagagggaaagcagcctagattctcccac
cggattccgctgctgatctttgatcaggatgagaagggc
aaggccagggacttcttcacagggaggaagcggaaagtc
ggcggtagcatcattcacaaggcttcaaatgtcatgcac
atcgagtccaagcaagtggtgggattccaactgtgctca
aatgacacctccgactgtgccacctacaccttcagctcg
ggaatcaatgccattcaggagtggtataagctacactac
atgaacatcatggcacaggtgcctctggagaagaaaatc
aacatgagctattctgctgaggagctgctggtgacctgc
ttctttgatggagtgtcctgtgatgccaggaatttcacg
cttttccaccacccgatgcatgggaattgctatactttc
aacaacagagaaaatgagaccattctcagcacctccatg
gggggcagcgaatatgggctgcaagtcattttgtacata
aacgaagaggaatacaacccattcctcgtgtcctccact
ggagctaaggtgatcatccatcggcaggatgagtatccc
ttcgtcgaagatgtgggaacagagattgagacagcaatg
gtcacctctataggaatgcacctgacagagtccttcaag
ctgagtgagccctacagtcagtgcacggaggacgggagt
gacgtgccaatcaggaacatctacaacgctgcctactcg
ctccagatctgccttcattcatgcttccagacaaagatg
gtggagaaatgtgggtgtgcccagtacagccagcctcta
cctcctgcagccaactactgcaactaccagcagcacccc
aactggatgtattgttactaccaactgcatcgagccttt
gtccaggaagagctgggctgccagtctgtgtgcaaggaa
gcctgcagctttaaagagtggacactaaccacaagcctg
gcacaatggccatctgtggtttcggagaagtggttgctg
cctgttctcacttgggaccaaggccggcaagtaaacaaa
aagctcaacaagacagacttggccaaactcttgatattc
tacaaagacctgaaccagagatccatcatggagagccca
gccaacagtattgagatgcttctgtccaacttcggtggc
cagctgggcctgtggatgagctgctctgttgtctgcgtc
atcgagatcatcgaggtcttcttcattgacttcttctct
atcattgcccgccgccagtggcagaaagccaaggagtgg
tgggcctggaaacaggctcccccatgtccagaagctccc
cgtagcccacagggccaggacaatccagccctggatata
gacgatgacctacccactttcaactctgctttgcacctg
cctccagccctaggaacccaagtgcccggcacaccgccc
cccaaatacaataccttgcgcttggagagggccttttcc
aaccagctcacagatacccagatgctggatgagctctga

other info1 :

Vector: Please Inquire

ncbi gi num :

37589553

ncbi acc num :

BC059391

ncbi mol weight :

74,270 Da

ncbi pathways :

Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Ion Channel Transport Pathway (187193); Stimuli-sensing Channels Pathway (771568); Taste Transduction Pathway (83088); Taste Transduction Pathway (499); Transmembrane Transport Of Small Molecules Pathway (106572)

ncbi summary :

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]

uniprot summary :

ENaC-gamma: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1G are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. Protein type: Transporter, ion channel; Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 16p12. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: amiloride-sensitive sodium channel activity; ion channel activity; protein binding; sodium channel activity; WW domain binding. Biological Process: excretion; multicellular organismal water homeostasis; sodium ion homeostasis; sodium ion transport. Disease: Bronchiectasis With Or Without Elevated Sweat Chloride 3; Liddle Syndrome; Pseudohypoaldosteronism, Type I, Autosomal Recessive

size1 :

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

price1 :

165 USD

more info or order :

MyBioSource product webpage