PROX1 Polyclonal Antibody | MyBioSource MBS127552 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PROX1 Polyclonal Antibody

catalog :

MBS127552

quantity :

0.1 mL

price :

275 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of mouse eye, using PROX1 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.

product information

catalog number :

MBS127552

products type :

Antibody

products full name :

PROX1 Polyclonal Antibody

products short name :

[PROX1]

products name syn :

[PROX1]

other names :

[Prospero homeobox protein 1; Prospero homeobox protein 1; prospero homeobox protein 1; prospero-related homeobox 1; homeobox prospero-like protein PROX1; prospero homeobox 1; Homeobox prospero-like protein PROX1; PROX-1]

products gene name :

[PROX1]

other gene names :

[PROX1; PROX1; PROX-1]

uniprot entry name :

PROX1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

737

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1:200 - 1:500. IHC: 1:50 - 1:100

image1 heading :

Western Blot (WB)

other info1 :

Species: Human. Immunogen: Recombinant Protein

other info2 :

Category: Primary antibody. Immunogen: Recombinant protein of human PROX1. Calculated Molecular Weight: 83kDa

products categories :

Polyclonal

products description :

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

ncbi gi num :

85702224

ncbi acc num :

Q92786.2

uniprot acc num :

Q92786

ncbi mol weight :

737

ncbi summary :

uniprot summary :

PROX1: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. Belongs to the Prospero homeobox family. Protein type: DNA-binding; Transcription factor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 1q41. Cellular Component: cytoplasm; nucleus. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor binding; protein binding; DBD domain binding; DNA binding; LBD domain binding; transcription factor activity; transcription corepressor activity. Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; circadian rhythm; neural tube development; positive regulation of cyclin-dependent protein kinase activity; ventricular cardiac myofibril development; muscle thin filament assembly; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; olfactory placode formation; negative regulation of cell proliferation; venous blood vessel morphogenesis; pancreas development; positive regulation of cell proliferation; lymphangiogenesis; ventricular cardiac muscle morphogenesis; kidney development; response to nutrient levels; dentate gyrus development; negative regulation of transcription factor activity; positive regulation of cell cycle; liver development; regulation of circadian rhythm; cerebellar granule cell differentiation; dorsal spinal cord development; negative regulation of viral genome replication; regulation of gene expression; otic placode formation; embryonic retina morphogenesis in camera-type eye; positive regulation of endothelial cell proliferation; optic placode formation involved in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; retina morphogenesis in camera-type eye; lung development

size1 :

0.1 mL

price1 :

275 USD

size2 :

0.2 mL

price2 :

430

more info or order :

MyBioSource product webpage