MDM4 cDNA Clone | MyBioSource MBS1275346 product information

product summary

company name :

MyBioSource

product type :

cDNA

product name :

MDM4 cDNA Clone

catalog :

MBS1275346

quantity :

0.01 mg Plasmid + 0.

price :

165 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1275346

products type :

cDNA Clone

products full name :

MDM4 cDNA Clone

products short name :

MDM4

other names :

Homo sapiens Mdm4 p53 binding protein homolog (mouse), mRNA; Protein Mdm4; protein Mdm4; MDM4, p53 regulator; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4

products gene name :

MDM4

other gene names :

MDM4; MDM4; HDMX; MDMX; MRP1; MDMX

uniprot entry name :

MDM4_HUMAN

sequence length :

1701

sequence :

atgacatcattttccacctctgctcagtgttcaacatct
gacagtgcttgcaggatctctcctggacaaatcaatcag
gtacgaccaaaactgccgcttttgaagattttgcatgca
gcaggtgcgcaaggtgaaatgttcactgttaaagaggtc
atgcactatttaggtcagtacataatggtgaagcaactt
tatgatcagcaggagcagcatatggtatattgtggtgga
gatcttttgggagaactactgggacgtcagagcttctcc
gtgaaagacccaagccctctctatgatatgctaagaaag
aatcttgtcactttagccactgctactacagatgctgct
cagactctcgctctcgcacaggatcacagtatggatatt
ccaagtcaagaccaactgaagcaaagtgcagaggaaagt
tccacttccagaaaaagaactacagaagacgatatcccc
acactgcctacctcagagcataaatgcatacattctaga
gaagatgaagacttaattgaaaatttagcccaagatgaa
acatctaggctggaccttggatttgaggagtgggatgta
gctggcctgccttggtggtttttaggaaacttgagaagc
aactatacacctagaagtaatggctcaactgatttacag
acaaatcaggatgtgggtactgccattgtttcagatact
acagatgacttgtggtttttgaatgagtcagtatcagag
cagttaggtgttggaataaaagttgaagctgctgatact
gaacaaacaagtgaagaagtagggaaagtaagtgacaaa
aaggtgattgaagtgggaaaaaatgatgacctggaggac
tctaagtccttaagtgatgataccgatgtagaggttacc
tctgaggatgagtggcagtgtactgaatgcaagaaattt
aactctccaagcaagaggtactgttttcgttgttgggcc
ttgaggaaggattggtattcagattgttcaaagttaacc
cattctctctccacgtctgatatcactgccatacctgaa
aaggaaaatgaaggaaatgatgtccctgattgtcgaaga
accatttcggctcctgtcgttagacctaaagatgcgtat
ataaagaaagaaaactccaaactttttgatccctgcaac
tcagtggaattcttggatttggctcacagttctgaaagc
caagagaccatctcaagcatgggagaacagttagataac
ctttctgaacagagaacagatacagaaaacatggaggat
tgccagaatctcttgaagccatgtagcttatgtgagaaa
agaccacgagacgggaacattattcatggaaggacgggc
catcttgtcacttgttttcactgtgccagaagactaaag
aaggctggggcttcatgccctatttgcaagaaagagatt
cagctggttattaaggtttttatagcataa

other info1 :

Vector: Please Inquire

ncbi gi num :

45501364

ncbi acc num :

BC067299

ncbi mol weight :

49,541 Da

ncbi pathways :

Signaling Pathways In Glioblastoma (672458); P53 Pathway (138067); P53 Signaling Pathway (83055); P53 Signaling Pathway (465)

ncbi summary :

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

uniprot summary :

MDM4: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. Interacts with MDM2, TP53, TP73 and USP2. Found in a trimeric complex with UPB2, MDM2 and MDM4. Interacts (phosphorylated) with YWHAG; negatively regulates MDM4 activity toward TP53. Down-regulated by cisplatin. Expressed in all tissues tested with high levels in thymus. Belongs to the MDM2/MDM4 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin ligase; EC 6.3.2.-; Ligase; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: nucleoplasm; nucleus. Molecular Function: enzyme binding; protein binding; zinc ion binding. Biological Process: cell proliferation; DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G0 to G1 transition; negative regulation of cell proliferation; negative regulation of protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; protein complex assembly; protein stabilization

size1 :

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

price1 :

165 USD

more info or order :

MyBioSource product webpage