product summary
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company name :
MyBioSource
product type :
cDNA
product name :
IGHG1 cDNA Clone
catalog :
MBS1275256
quantity :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1275256
products type :
cDNA Clone
products full name :
IGHG1 cDNA Clone
products short name :
[IGHG1]
other names :
[Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker), mRNA; Ig gamma-1 chain C region; immunoglobulin heavy constant gamma 1 (G1m marker)]
products gene name :
[IGHG1]
other gene names :
[IGHG1; IGHG1]
uniprot entry name :
IGHG1_HUMAN
sequence length :
1440
sequence :
atgaaatttgggctgagctggattttccttcctgctata
ttaaaaggtgtccagtgtgaggtgcagctggtggagtct
gggggaggcttggtaaaggcgggggggtccctaagactc
tcctgtgcagcctctggattcagtttcagtgatgcctgg
atgagctgggcccgccagcctccagggaaggggctggag
tggcttggccgcattaaaaggaaaagtgatggtgggaca
acagagtacgctgcacacgtgaaaggcagattcatcatc
tctagagacgactcaaaatacatggtgtatatgcagatg
aacagtctgaagaccgaggacacggccgtctattactgt
aatacagatgcccgctcagtaggatccttggagtggccc
aattattatcacggtatgaacgtctggggtgaagggacc
acggtcaccgtctcttcagcctccaccaagggcccatcg
gtcttccccctggcaccctcctccaagagcacctctggg
ggcacagcggccctgggctgcctggtcaaggactacttc
cccgaaccggtgacggtgtcgtggaactcaggcgccctg
accagcggcgtgcacaccttcccggctgtcctacagtcc
tcaggactctactccctcagcagcgtggtgaccgtgccc
tccagcagcttgggcacccagacctacatctgcaacgtg
aatcacaagcccagcaacaccaaggtggacaagaaagtt
gagcccaaatcttgtgacaaaactcacacatgcccaccg
tgcccagcacctgaactcctggggggaccgtcagtcttc
ctcttccccccaaaacccaaggacaccctcatgatctcc
cggacccctgaggtcacatgcgtggtggtggacgtgagc
cacgaagaccctgaggtcaagttcaactggtacgtggac
ggcgtggaggtgcataatgccaagacaaagccgcgggag
gagcagtacaacagcacgtaccgtgtggtcagcgtcctc
accgtcctgcaccaggactggctgaatggcaaggagtac
aagtgcaaggtctccaacaaagccctcccagcccccatc
gagaaaaccatctccaaagccaaagggcagccccgagaa
ccacaggtgtacaccctgcccccatcccgggatgagctg
accaagaaccaggtcagcctgacctgcctggtcaaaggc
ttctatcccagcgacatcgccgtggagtgggagagcaat
gggcagccggagaacaactacaagaccacgcctcccgtg
ctggactccgacggctccttcttcctctacagcaagctc
accgtggacaagagcaggtggcagcaggggaacgtcttc
tcatgctccgtgatgcatgaggctctgcacaaccactac
acgcagaagagcctctccctgtctccgggtaaatga
other info1 :
Vector: pENTR223.1
other info2 :
Clone Sequence Report: Provided with product shipment
products description :
Homo sapiens immunoglobulin heavy constant gamma 1 (G1m marker), mRNA (cDNA clone IMAGE:4850078)
ncbi gi num :
15779221
ncbi acc num :
BC014667
uniprot acc num :
P01857
ncbi mol weight :
36,106 Da
ncbi pathways :
Classical Antibody-mediated Complement Activation Pathway (106409); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); FCGR Activation Pathway (771578); Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway (771577); IL4-mediated Signaling Events Pathway (137933); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway (771579)
uniprot summary :
IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. Protein type: Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; antigen binding. Biological Process: innate immune response; complement activation, classical pathway; complement activation. Disease: Myeloma, Multiple
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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