CNR1 Polyclonal Antibody | MyBioSource MBS127520 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CNR1 Polyclonal Antibody

catalog :

MBS127520

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

unidentified

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of NIH3T3 cells, using CNR1 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.

product information

catalog number :

MBS127520

products type :

Antibody

products full name :

CNR1 Polyclonal Antibody

products short name :

[CNR1]

products name syn :

[CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR]

other names :

[Cannabinoid receptor 1; Cannabinoid receptor 1; cannabinoid receptor 1; central cannabinoid receptor; cannabinoid receptor 1 (brain); CANN6]

products gene name :

[CNR1]

other gene names :

[CNR1; CNR1; CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5; CNR; CB-R; CB1]

uniprot entry name :

CNR1_HUMAN

clonality :

polyclonal

isotype :

IgG

host :

unknown

reactivity :

Human, Mouse, Rat

sequence length :

472

purity :

Affinity Purification

storage stability :

Store at -20°C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1:500 - 1:2000

image1 heading :

Western Blot (WB)

other info1 :

Source: Rabbit

other info2 :

Immunogen: Recombinant protein of human CNR1. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Polyclonal

products description :

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9- tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G- protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose- dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

ncbi gi num :

115562

ncbi acc num :

P21554.1

uniprot acc num :

P21554

ncbi mol weight :

53kDa

ncbi pathways :

BDNF Signaling Pathway (712093); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); N-cadherin Signaling Events Pathway (137919)

ncbi summary :

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

uniprot summary :

CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 6q14-q15. Cellular Component: growth cone; intracellular membrane-bound organelle; integral to plasma membrane; axon; plasma membrane. Molecular Function: cannabinoid receptor activity; drug binding. Biological Process: response to nicotine; negative regulation of mast cell activation; maternal process involved in pregnancy; negative regulation of fatty acid beta-oxidation; regulation of synaptic transmission, glutamatergic; negative regulation of nitric-oxide synthase activity; positive regulation of apoptosis; axonal fasciculation; response to morphine; positive regulation of acute inflammatory response to antigenic stimulus; response to lipopolysaccharide; negative regulation of action potential; sensory perception of pain; glucose homeostasis; response to cocaine; regulation of synaptic transmission, GABAergic; memory; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; positive regulation of fever; spermatogenesis; negative regulation of blood pressure; negative regulation of dopamine secretion; regulation of insulin secretion; response to nutrient; positive regulation of blood pressure; aging

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage