AATF cDNA Clone | MyBioSource MBS1275193 product information

product summary

company name :

MyBioSource

product type :

cDNA

product name :

AATF cDNA Clone

catalog :

MBS1275193

quantity :

10 ug Plasmid + 200

price :

175 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1275193

products type :

cDNA Clone

products full name :

AATF cDNA Clone

products short name :

AATF

other names :

Homo sapiens apoptosis antagonizing transcription factor, mRNA; Protein AATF; protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1

products gene name :

AATF

other gene names :

AATF; AATF; DED; CHE1; CHE-1; CHE1; DED

uniprot entry name :

AATF_HUMAN

sequence length :

2052

sequence :

atggcggggccgcagcccctggcgctgcaactggaacag
ttgttgaacccgcgaccaagcgaggcggaccctgaagcg
gaccccgaggaagccactgctgccagggtgattgacagg
tttgatgaaggggaagatggggaaggtgatttcctagta
gtgggtagcattagaaaactggcatcagcctccctcttg
gacacggacaaaaggtattgcggcaaaaccacctctaga
aaagcatggaatgaagaccattgggagcagactctgcca
ggatcgtctgatgaggaaatatctgatgaggaagggtct
ggagatgaagattcagagggactgggtctggaggaatat
gatgaggacgacctgggtgctgctgaggaacaggagtgt
ggtgatcacagggagagcaagaagagcagaagccactct
gcaaaaacaccgggcttcagtgtccagagtatcagtgac
tttgagaaatttaccaagggaatggatgaccttgggagc
agtgaggaggaggaagacgaagagagtggcatggaagaa
ggggatgacgcggaagactcccaaggcgagagtgaggaa
gacagggctggagatagaaacagtgaggatgatggtgtg
gtgatgaccttctctagtgtcaaagtttctgaggaagtg
gagaaaggaagagccgtgaagaaccagatagcactgtgg
gaccagctcttggaaggaaggatcaaactacaaaaagct
ctgttgaccaccaaccagcttcctcaaccagatgttttc
ccattgttcaaggacaaaggtggcccagaattttccagt
gccctgaaaaatagtcacaaggcacttaaagcattgttg
aggtcattggtaggtcttcaggaagagttgcttttccag
tacccagacactagatatctagtagatgggacaaagccc
aatgcgggaagtgaggagatttctagtgaagatgatgag
ctggtagaagagaagaagcagcaacgaagaagggtccct
gcaaagaggaagctggagatggaggactatcccagcttc
atggcaaagcgctttgccgactttacagtctacaggaac
cgcacacttcagaaatggcacgataagaccaaactggct
tctggaaaactggggaagggttttggtgcctttgaacgc
tcaatcttgactcagatcgaccatattctgatggacaaa
gagagattacttcgaaggacacagaccaagcgctctgtc
tatcgagttcttggcaaacctgagccagcagctcagcct
gtcccagagagtttgccaggggaaccggagatccttcct
caagcccctgctaatgctcatctgaaggacttggatgaa
gaaatctttgatgatgatgacttttaccaccagctcctt
cgagaactcatagaacggaagaccagctccttggatccc
aacgatcaggtggccatgggaaggcagtggcttgcaatc
cagaagttacgaagcaaaatccacaaaaaagtagatagg
aaagccagcaaaggcaggaaacttcggtttcatgtcctt
agcaagctactgagtttcatggcacctattgaccatact
acaatgaatgatgatgccaggacagaactgtaccgctct
ctttttggccagctccaccctcccgacgaaggccacggg
gattga

other info1 :

Vector: pENTR223.1

ncbi gi num :

33875610

ncbi acc num :

BC000591

uniprot acc num :

Q9NY61

ncbi mol weight :

63,133 Da

ncbi pathways :

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!NRAGE Signals Death Through JNK Pathway 106444!!Regulation Of Retinoblastoma Protein Pathway 137916!!Signal Transduction Pathway 477114!!Signalling By NGF Pathway 106439!!P75 NTR Receptor-mediated Signalling Pathway 106441

ncbi summary :

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Ref.8 Ref.10 Ref.12 Ref.13. Subunit structure: Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT. Subcellular location: Nucleus nucleolus Ref.9. Tissue specificity: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. Ref.1 Ref.2. Post-translational modification: Hyperphosphorylated during the G1/S phase transition. Ref.8. Sequence similarities: Belongs to the AATF family. Sequence caution: The sequence AAD52016.1 differs from that shown. Reason: Frameshift at positions 355, 365, 487, 498 and 503.

size :

10 ug Plasmid + 200 ul Glycerol Stock

price :

175 USD

more info or order :

MyBioSource product webpage