product summary
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company name :
MyBioSource
product type :
antibody
product name :
MUC20 Polyclonal Antibody
catalog :
MBS127501
quantity :
0.05 mL
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
more info or order :
product information
catalog number :
MBS127501
products type :
Antibody
products full name :
MUC20 Polyclonal Antibody
products short name :
MUC20
products name syn :
MUC-20
other names :
Mucin-20; Mucin-20; mucin-20; transmembrane mucin MUC20S; mucin 20, cell surface associated
products gene name :
MUC20
other gene names :
MUC20; MUC20; MUC-20; KIAA1359; MUC-20
uniprot entry name :
MUC20_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
709
purity :
Affinity Purification
concentration :
1mg/ml
storage stability :
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500 - 1:2000. IHC: 1:25 - 1:100
other info1 :
Species: Human. Immunogen: Recombinant Protein
other info2 :
Immunogen: Recombinant protein of human MUC20. Calculated Molecular Weight: 72kDa
products categories :
Polyclonal
products description :
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified.
ncbi gi num :
317373415
ncbi acc num :
Q8N307.3
uniprot acc num :
Q8N307
ncbi mol weight :
538
ncbi pathways :
Metabolism Of Proteins Pathway (106230); O-linked Glycosylation Pathway (1127679); O-linked Glycosylation Of Mucins Pathway (530747); Post-translational Protein Modification Pathway (161012); Signaling Events Mediated By Hepatocyte Growth Factor Receptor (c-Met) Pathway (137930); Termination Of O-glycan Biosynthesis Pathway (530748)
ncbi summary :
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The C-terminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]
uniprot summary :
MUC20: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. 2 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: Golgi lumen; microvillus membrane; apical plasma membrane; basal plasma membrane; extracellular region. Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; activation of MAPK activity; hepatocyte growth factor receptor signaling pathway; post-translational protein modification; protein homooligomerization
size1 :
0.05 mL
price1 :
230 USD
size2 :
0.1 mL
price2 :
305
size3 :
0.2 mL
price3 :
460
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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