product summary
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company name :
MyBioSource
product type :
cDNA
product name :
TXNDC3 cDNA Clone
catalog :
MBS1274458
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1274458
products type :
cDNA Clone
products full name :
TXNDC3 cDNA Clone
products short name :
TXNDC3
other names :
Homo sapiens thioredoxin domain containing 3 (spermatozoa), mRNA; Thioredoxin domain-containing protein 3; thioredoxin domain-containing protein 3; NME/NM23 family member 8; NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2
products gene name :
TXNDC3
other gene names :
NME8; NME8; CILD6; SPTRX2; TXNDC3; NM23-H8; sptrx-2; HEL-S-99; SPTRX2; TXNDC3; Sptrx-2
uniprot entry name :
TXND3_HUMAN
sequence length :
2350
sequence :
atggcaagcaaaaaacgagaagtccagttacagacagtc
atcaataatcaaagcctgtgggatgagatgttgcagaac
aaaggcttaacagtgattgatgtttaccaagcctggtgt
ggaccttgcagagcaatgcaacctttattcagaaaattg
aaaaatgaactgaacgaagacgaaattctgcattttgct
gtcgcagaagctgacaacattgtgactttgcagccattt
agagataaatgtgaacctgtttttctctttagtgttaat
ggcaaaattatcgaaaagattcagggtgcaaatgcaccg
cttgttaataaaaaagttattaatttgatcgatgaggag
agaaaaattgcagcaggtgaaatggctcgacctcagtat
cctgaaattccattagtagactcagattcagaagttagt
gaagaatcaccatgtgaaagtgttcaggaattatacagt
attgctattatcaaaccggatgctgtgattagtaaaaaa
gttctagaaattaaaagaaaaattaccaaagctggattt
attatagaagcagagcataagacagtgctcactgaagaa
caagttgtcaacttctatagtcgaatagcagaccagcgt
gacttcgaagagtttgtctcttttatgacaagtggctta
agctatattctagttgtatctcaaggaagtaaacacaat
cctccctctgaagaaaccgaaccacagactgacaccgaa
cctaacgaacgatctgaggatcaacctgaggtcgaagcc
caggttacacctggaatgatgaagaacaaacaagacagt
ttacaagaatatctggaaagacaacatttagctcagctc
tgtgacattgaagaggatgcagctaatgttgctaagttc
atggatgctttcttccccgattttaaaaaaatgaaaagc
atgaaattagaaaagacattggcattacttcgaccaaat
ctctttcatgaaaggaaagatgatgttttgcgtattatt
aaagatgaagacttcaaaatactggagcaaagacaagta
gtattatcggaaaaagaagcacaagcactgtgcaaggaa
tatgaaaatgaagactattttaataaacttatagaaaac
atgaccagtggtccatctctagcccttgttttattgaga
gacaatggcttgcaatactggaaacaattactgggacca
agaactgttgaagaagccattgaatattttccagagagt
ttatgtgcacagtttgcgatggacagtttgccggtcaac
cagttgtatggcagcgattcattagaaaccgctgaaagg
gaaatacagcatttctttcctcttcaaagcactttaggc
ttgattaaacctcatgcaacaagtgaacaaagagagcag
atcctgaagatagttaaggaggctggatttgatctgaca
caggtgaagaaaatgttcctaactcctgagcaaactgag
aaaatttatccaaaagtaacaggaaaagacttttataaa
gatttattggaaatgttatctgtgggtccatctatggtc
atgattctgaccaagtggaatgctgttgcagaatggaga
cgattgatgggcccaacagacccagaagaagcaaaatta
ctttcccctgactccatccgagcccagtttggaataagt
aaattgaaaaacattgtccatggagcatctaacgcctat
gaagcaaaagaggttgttaatagactctttgaggatcct
gaggaaaactaa
other info1 :
Vector: Please Inquire
ncbi gi num :
22477641
ncbi acc num :
BC036816
ncbi mol weight :
67,270 Da
ncbi summary :
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
uniprot summary :
TXNDC3: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Protein type: Oxidoreductase; Kinase, nucleoside diphosphate; Other group; NDK family. Chromosomal Location of Human Ortholog: 7p14.1. Molecular Function: microtubule binding; nucleoside diphosphate kinase activity. Biological Process: cilium biogenesis. Disease: Ciliary Dyskinesia, Primary, 6
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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