cDNA

ABCG8 cDNA Clone

MBS1274421

0.01 mg Plasmid + 0.

165 USD

cDNA Clone

ABCG8 cDNA Clone

ABCG8

Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 8, mRNA; ATP-binding cassette sub-family G member 8; ATP-binding cassette sub-family G member 8; ATP binding cassette subfamily G member 8; Sterolin-2

ABCG8

ABCG8; ABCG8; GBD4; STSL

ABCG8_HUMAN

2147

atggccgggaaggcggcagaggagagagggctgccgaaa
ggggccactccccagcatacctcgggcctccaggataga
ttgttctcctctgaaagtgacaacagcctgtacttcacc
tacagtggccagcccaacaccctggaggtcagagacctc
aactaccaggtggacctggcctctcaggtcccttggttt
gagcagctggctcagttcaagatgccctggacatctccc
agctgccagaattcttgtgagctgggcatccagaaccta
agcttcaaagtgagaagtgggcagatgctggccatcata
gggagctcaggttgtgggagagcctccttgctagatgtg
atcactggccgaggtcacggcggcaagatcaagtcaggc
cagatctggatcaatgggcagcccagctcgcctcagctg
gtgaggaagtgtgtggcccacgtgcgccagcacaaccag
ctgctccccaacttgactgtgcgagagaccttggccttc
attgcccagatgcggctgcccagaaccttctcccaggcc
cagcgtgacaaaagggtggaggacgtgatcgcggagctg
cggcttaggcagtgcgctgacacccgcgtgggcaacatg
tacgtgcgggggttgtcggggggtgagcgcaggagagtc
agcattggggtgcagctcctgtggaacccaggaatcctt
attctcgacgaacccacctctgggctcgacagcttcaca
gcccacaacctggtgaagaccttgtccaggctggccaaa
ggcaaccggctggtgctcatctccctccaccagcctcgc
tctgacatcttcaggctgtttgatctggtcctcctgatg
acgtctggcacccccatctacttaggggcggcccagcac
atggtccagtatttcacagccatcggctacccctgtcct
cgctacagcaatcctgctgacttctatgtggacctgacc
agcattgacaggcgcagcagagagcaggaattggccacc
agggagaaggctcagtcactcgcagccctgtttctagaa
aaagtgcgtgacttagatgactttctatggaaagcagag
acgaaggatcttgacgaggacacctgtgtggaaagcagc
gtgaccccactagacaccaactgcctcccgagtcctacg
aagatgcctggggcggtgcagcagtttacgacgctgatc
cgtcgtcagatttccaacgacttccgagacctgcccacc
ctcctcatccatggggcggaggcctgtctgatgtcaatg
accatcggcttcctctattttggccatgggagcatccag
ctctccttcatggatacagccgccctcttgttcatgatc
ggtgctctcatccctttcaacgtcattctggatgtcatc
tccaaatgttactcagagagggcaatgctttactatgaa
ctggaagacgggctgtacaccactggtccatatttcttt
gccaagatcctcggggagcttccggagcactgtgcctac
atcatcatctacgggatgcccacctactggctggccaac
ctgaggccaggcctccagcccttcctgctgcacttcctg
ctggtgtggctggtggtcttctgttgcaggattatggcc
ctggccgccgcggccctgctccccaccttccacatggcc
tccttcttcagcaatgccctctacaactccttctacctc
gccgggggcttcatgataaacttgagcagcctgtggaca
gtgcccgcgtggatttccaaagtgtccttcctgcggtgg
tgttttgaagggctgatgaagattcagttcagcagaaga
acttataaaatgcctctcgggaacctcaccatcgcggtc
tcaggagataaaatcctcagtgccatggagctggactcg
taccctctctacgccatctacctcatcgtcattggcctc
agcggtggcttcatggtcctgtactacgtgtccttaagg
ttcatcaaacagaaaccaagtcaagactggtga

Vector: Please Inquire

109731354

BC113657

75,592 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolism Pathway (477135)

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]

ABCG8: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4). With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries. Defects in ABCG8 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Transporter, ABC family; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2p21. Cellular Component: apical plasma membrane; ATP-binding cassette (ABC) transporter complex; plasma membrane; receptor complex. Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; protein binding; protein heterodimerization activity. Biological Process: cholesterol absorption; cholesterol efflux; cholesterol homeostasis; excretion; negative regulation of cholesterol absorption; sterol transport; transmembrane transport. Disease: Gallbladder Disease 4; Sitosterolemia

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

165 USD