NPY Polyclonal Antibody | MyBioSource MBS127399 product information

product summary

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company name :

MyBioSource

product type :

antibody

product name :

NPY Polyclonal Antibody

catalog :

MBS127399

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry of paraffin-embedded rat brain using NPY antibody at dilution of 1:75 (40x lens).

image 2 :

Immunohistochemistry of paraffin-embedded mouse brain using NPY antibody at dilution of 1:75 (40x lens).

product information

catalog number :

MBS127399

products type :

Antibody

products full name :

NPY Polyclonal Antibody

products short name :

[NPY]

products name syn :

[NPY, PYY4, neuropeptide Y]

other names :

[Pro-neuropeptide Y; Pro-neuropeptide Y; pro-neuropeptide Y; prepro-neuropeptide Y; neuropeptide Y; Neuropeptide tyrosine; NPY]

products gene name :

[NPY]

other gene names :

[NPY; NPY; PYY4; NPY; CPON]

uniprot entry name :

NPY_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

purity :

Affinity Purification

form :

PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

storage stability :

Store at -20°C. Avoid freeze/thaw cycles.

tested application :

Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Recommended Dilutions: . IHC: 1:50 - 1:200. IF: 1:50 - 1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human NPY (NP_000896.1).

products categories :

Polyclonal

products description :

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi.

ncbi gi num :

128117

ncbi acc num :

P01303.1

uniprot acc num :

P01303

ncbi mol weight :

10 kDa

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); Endothelin Pathway (672453); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

uniprot summary :

NPY: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. Belongs to the NPY family. Protein type: Secreted; Secreted, signal peptide; Hormone. Chromosomal Location of Human Ortholog: 7p15.1. Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region. Molecular Function: G-protein coupled receptor activity; neuropeptide hormone activity; neuropeptide Y receptor binding; calcium channel regulator activity; receptor binding. Biological Process: blood circulation; behavior; adult feeding behavior; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell proliferation; neuropeptide signaling pathway; regulation of blood pressure; calcium ion transport; positive regulation of appetite; regulation of appetite; digestion; feeding behavior; cerebral cortex development; cell motility; neurite development; central nervous system neuron development

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage