product summary
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company name :
MyBioSource
product type :
cDNA
product name :
ATG4A cDNA Clone
catalog :
MBS1271931
quantity :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1271931
products type :
cDNA Clone
products full name :
ATG4A cDNA Clone
products short name :
[ATG4A]
other names :
[Homo sapiens ATG4 autophagy related 4 homolog A (S. cerevisiae), mRNA; Cysteine protease ATG4A; cysteine protease ATG4A; autophagy related 4A cysteine peptidase; AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; hAPG4A]
products gene name :
[ATG4A]
other gene names :
[ATG4A; ATG4A; APG4A; AUTL2; APG4A; AUTL2; hAPG4A]
uniprot entry name :
ATG4A_HUMAN
sequence length :
1197
sequence :
atggagtcagttttatccaagtatgaagatcagattact
attttcactgactacctagaagaatatccagatacagat
gagctggtatggatcttagggaagcagcatctccttaaa
acagaaaaatctaagctgttgtctgatataagtgctcgt
ctatggtttacatacagaaggaaattttcaccaattggt
ggaacgggcccttcatcagatgctggttggggatgtatg
ctacgctgtggacagatgatgctggctcaagcccttatc
tgtagacacttgggaagggactggagctgggagaaacaa
aaagaacaacccaaagaataccaacgcatcctacagtgc
ttcttagatagaaaagattgttgctactctatccatcaa
atggcacaaatgggtgtaggagaagggaaatcaattgga
gaatggtttggaccaaatacagttgcacaggtgttaaaa
aaacttgctttatttgacgaatggaattccttggctgtt
tatgtttcaatggataacacagtggtcattgaagatatc
aaaaaaatgtgccgtgtccttcccttgagtgctgacaca
gctggtgacaggcctcccgattctttaactgcttcaaac
cagagtaagggcacctctgcctactgctcagcctggaaa
cccctgctgctcattgtgccccttcgcctgggcataaac
caaatcaatcctgtctatgttgatgcattcaaagagtgt
tttaagatgccacagtctttaggggcattaggaggaaaa
ccaaataacgcgtattatttcataggattcttaggtgac
gagctcatcttcttggaccctcatacaacccagaccttt
gttgacactgaagagaatggaacggttaatgaccagact
ttccattgcctgcagtccccacagcgaatgaacatccta
aacctggatccttcagttgcattgggatttttctgcaaa
gaagaaaaagactttgataactggtgtagccttgttcag
aaggaaattctaaaggagaatttaaggatgtttgaatta
gttcagaaacatccatcacactggcctccctttgtacct
ccagccaagccagaagtgacaaccactggggcagaattc
attgactctactgagcaactggaggagtttgatctggag
gaagattttgagattctgagtgtgtag
other info1 :
Vector: pENTR223.1
other info2 :
Clone Sequence Report: Provided with product shipment
ncbi gi num :
38197607
ncbi acc num :
BC061696
ncbi mol weight :
42,453 Da
ncbi pathways :
Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468)
ncbi summary :
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]
uniprot summary :
ATG4A: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Microtubule-binding; EC 3.4.22.-; Autophagy; Protease. Chromosomal Location of Human Ortholog: Xq22.3. Cellular Component: cytoplasm; cytosol. Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; protein binding. Biological Process: autophagic vacuole formation; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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