product summary
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company name :
MyBioSource
product type :
cDNA
product name :
IL6ST cDNA Clone
catalog :
MBS1271170
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1271170
products type :
cDNA Clone
products full name :
IL6ST cDNA Clone
products short name :
IL6ST
other names :
Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor), mRNA; Interleukin-6 receptor subunit beta; interleukin-6 receptor subunit beta; interleukin 6 signal transducer; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
products gene name :
IL6ST
other gene names :
IL6ST; IL6ST; CD130; GP130; CDW130; IL-6RB; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130
uniprot entry name :
IL6RB_HUMAN
sequence length :
2985
sequence :
atgttgacgttgcagacttggctagtgcaagccttgttt
attttcctcaccactgaatctacaggtgaacttctagat
ccatgtggttatatcagtcctgaatctccagttgtacaa
cttcattctaatttcactgcagtttgtgtgctaaaggaa
aaatgtatggattattttcatgtaaatgctaattacatt
gtctggaaaacaaaccattttactattcctaaggagcaa
tatactatcataaacagaacagcatccagtgtcaccttt
acagatatagcttcattaaatattcagctcacttgcaac
attcttacattcggacagcttgaacagaatgtttatgga
atcacaataatttcaggcttgcctccagaaaaacctaaa
aatttgagttgcattgtgaacgaggggaagaaaatgagg
tgtgagtgggatcgtggaagggaaacacacttggagaca
aacttcactttaaaatctgaatgggcaacacacaagttt
gctgattgcaaagcaaaacgtgacacccccacctcatgc
actgttgattattctactgtgtattttgtcaacattgaa
gtctgggtagaagcagagaatgcccttgggaaggttaca
tcagatcatatcaattttgatcctgtatataaagtgaag
cccaatccgccacataatttatcagtgatcaactcagag
gaactgtctagtatcttaaaattgacatggaccaaccca
agtattaagagtgttataatactaaaatataacattcaa
tataggaccaaagatgcctcaacttggagccagattcct
cctgaagacacagcatccacccgatcttcattcactgtc
caagaccttaaaccttttacagaatatgtgtttaggatt
cgctgtatgaaggaagatggtaagggatactggagtgac
tggagtgaagaagcaagtgggatcacctatgaagataga
ccatctaaagcaccaagtttctggtataaaatagatcca
tcccatactcaaggctacagaactgtacaactcgtgtgg
aagacattgcctccttttgaagccaatggaaaaatcttg
gattatgaagtgactctcacaagatggaaatcacattta
caaaattacacagttaatgccacaaaactgacagtaaat
ctcacaaatgatcgctatgtagcaaccctaacagtaaga
aatcttgttggcaaatcagatgcagctgttttaactatc
cctgcctgtgactttcaagctactcaccctgtaatggat
cttaaagcattccccaaagataacatgctttgggtggaa
tggactactccaagggaatctgtaaagaaatatatactt
gagtggtgtgtgttatcagataaagcaccctgtatcaca
gactggcaacaagaagatggtaccgtgcatcgcacctat
ttaagagggaacttagcagagagcaaatgctatttgata
acagttactccagtatatgctgatggaccaggaagccct
gaatccataaaggcataccttaaacaagctccaccttcc
aaaggacctactgttcggacaaaaaaagtagggaaaaac
gaagctgtcttagagtgggaccaacttcctgttgatgtt
cagaatggatttatcagaaattatactatattttataga
accatcattggaaatgaaactgctgtgaatgtggattct
tcccacacagaatatacattgtcctctttgactagtgac
acattgtacatggtacgaatggcagcatacacagatgaa
ggtgggaaggatggtccagaattcacttttactacccca
aagtttgctcaaggagaaattgaagccatagtcgtgcct
gtttgcttagcattcctattgacaactcttctgggagtg
ctgttctgctttaataagcgagacctaattaaaaaacac
atctggcctaatgttccagatccttcaaagagtcatatt
gcccagtggtcacctcacactcctccaaggcacaatttt
aattcaaaagatcaaatgtattcagatggcaatttcact
gatgtaagtgttgtggaaatagaagcaaatgacaaaaag
ccttttccagaagatctgaaatcattggacctgttcaaa
aaggaaaaaattaatactgaaggacacagcagtggtatt
ggggggtcttcatgcatgtcatcttctaggccaagcatt
tctagcagtgatgaaaatgaatcttcacaaaacacttcg
agcactgtccagtattctaccgtggtacacagtggctac
agacaccaagttccgtcagtccaagtcttctcaagatcc
gagtctacccagcccttgttagattcagaggagcggcca
gaagatctacaattagtagatcatgtagatggcggtgat
ggtattttgcccaggcaacagtacttcaaacagaactgc
agtcagcatgaatccagtccagatatttcacattttgaa
aggtcaaagcaagtttcatcagtcaatgaggaagatttt
gttagacttaaacagcagatttcagatcatatttcacaa
tcctgtggatctgggcaaatgaaaatgtttcaggaagtt
tctgcagcagatgcttttggtccaggtactgagggacaa
gtagaaagatttgaaacagttggcatggaggctgcgact
gatgaaggcatgcctaaaagttacttaccacagactgta
cggcaaggcggctacatgcctcagtga
other info1 :
Vector: Please Inquire
ncbi gi num :
109659085
ncbi acc num :
BC117402
ncbi mol weight :
96,276 Da
ncbi pathways :
Adipogenesis Pathway (198832); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL-6 Signaling Pathway (198864); IL27-mediated Signaling Events Pathway (137929); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Interleukin-11 Signaling Pathway (698753); Interleukin-6 Signaling Pathway (205111)
ncbi summary :
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
uniprot summary :
gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: extracellular region; interleukin-6 receptor complex; membrane; oncostatin-M receptor complex; plasma membrane. Molecular Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; interleukin-27 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; protein homodimerization activity. Biological Process: cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; negative regulation of apoptosis; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; response to cytokine stimulus
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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