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company name :
MyBioSource
product type :
cDNA
product name :
ATP2A2 cDNA Clone
catalog :
MBS1270114
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1270114
products type :
cDNA Clone
products full name :
ATP2A2 cDNA Clone
products short name :
ATP2A2
other names :
Homo sapiens ATPase, Ca++ transporting, cardiac muscle, slow twitch 2, mRNA; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
products gene name :
ATP2A2
other gene names :
ATP2A2; ATP2A2; DD; DAR; ATP2B; SERCA2; ATP2B; SERCA2; SR Ca(2+)-ATPase 2
uniprot entry name :
AT2A2_HUMAN
sequence length :
4152
sequence :
atggagaacgcgcacaccaagacggtggaggaggtgctg
ggccacttcggcgtcaacgagagtacggggctgagcctg
gaacaggtcaagaagcttaaggagagatggggctccaac
gagttaccggctgaagaaggaaaaaccttgctggaactt
gtgattgagcagtttgaagacttgctagttaggatttta
ttactggcagcatgtatatcttttgttttggcttggttt
gaagaaggtgaagaaacaattacagcctttgtagaacct
tttgtaattttactcatattagtagccaatgcaattgtg
ggtgtatggcaggaaagaaatgctgaaaatgccatcgaa
gcccttaaggaatatgagcctgaaatgggcaaagtgtat
cgacaggacagaaagagtgtgcagcggattaaagctaaa
gacatagttcctggtgatattgtagaaattgctgttggt
gacaaagttcctgctgatataaggttaacttccatcaaa
tctaccacactaagagttgaccagtcaattctcacaggt
gaatctgtctctgtcatcaagcacactgatcccgtccct
gacccacgagctgtcaaccaagataaaaagaacatgctg
ttttctggtacaaacattgctgctgggaaagctatggga
gtggtggtagcaactggagttaacaccgaaattggcaag
atccgggatgaaatggtggcaacagaacaggagagaaca
ccccttcagcaaaaactagatgaatttggggaacagctt
tccaaagtcatctcccttatttgcattgcagtctggatc
ataaatattgggcacttcaatgacccggttcatggaggg
tcctggatcagaggtgctatttactactttaaaattgca
gtggccctggctgtagcagccattcctgaaggtctgcct
gcagtcatcaccacctgcctggctcttggaactcgcaga
atggcaaagaaaaatgccattgttcgaagcctcccgtct
gtggaaacccttggttgtacttctgttatctgctcagac
aagactggtacacttacaacaaaccagatgtcagtctgc
aggatgttcattctggacagagtggaaggtgatacttgt
tcccttaatgagtttaccataactggatcaacttatgca
cctattggagaagtgcataaagatgataaaccagtgaat
tgtcaccagtatgatggtctggtagaattagcaacaatt
tgtgctctttgtaatgactctgctttggattacaatgag
gcaaagggtgtgtatgaaaaagttggagaagctacagag
actgctctcacttgcctagtagagaagatgaatgtattt
gataccgaattgaagggtctttctaaaatagaacgtgca
aatgcctgcaactcagtcattaaacagctgatgaaaaag
gaattcactctagagttttcacgtgacagaaagtcaatg
tcggtttactgtacaccaaataaaccaagcaggacatca
atgagcaagatgtttgtgaagggtgctcctgaaggtgtc
attgacaggtgcacccacattcgagttggaagtactaag
gttcctatgacctctggagtcaaacagaagatcatgtct
gtcattcgagagtggggtagtggcagcgacacactgcga
tgcctggccctggccactcatgacaacccactgagaaga
gaagaaatgcaccttgaggactctgccaactttattaaa
tatgagaccaatctgaccttcgttggctgcgtgggcatg
ctggatcctccgagaatcgaggtggcctcctccgtgaag
ctgtgccggcaagcaggcatccgggtcatcatgatcact
ggggacaacaagggcactgctgtggccatctgtcgccgc
atcggcatcttcgggcaggatgaggacgtgacgtcaaaa
gctttcacaggccgggagtttgatgaactcaacccctcc
gcccagcgagacgcctgcctgaacgcccgctgttttgct
cgagttgaaccctcccacaagtctaaaatcgtagaattt
cttcagtcttttgatgagattacagctatgactggcgat
ggcgtgaacgatgctcctgctctgaagaaagccgagatt
ggcattgctatgggctctggcactgcggtggctaaaacc
gcctctgagatggtcctggcggatgacaacttctccacc
attgtggctgccgttgaggaggggcgggcaatctacaac
aacatgaaacagttcatccgctacctcatctcgtccaac
gtcggggaagttgtctgtattttcctgacagcagccctt
ggatttcccgaggctttgattcctgttcagctgctctgg
gtcaatctggtgacagatggcctgcctgccactgcactg
gggttcaaccctcctgatctggacatcatgaataaacct
ccccggaacccaaaggaaccattgatcagcgggtggctc
tttttccgttacttggctattggctgttacgtcggcgct
gctaccgtgggtgctgctgcatggtggttcattgctgct
gacggtggtccaagagtgtccttctaccagctgagtcat
ttcctacagtgtaaagaggacaacccggactttgaaggc
gtggattgtgcaatctttgaatccccatacccgatgaca
atggcgctctctgttctagtaactatagaaatgtgtaac
gccctcaacagcttgtccgaaaaccagtccttgctgagg
atgcccccctgggagaacatctggctcgtgggctccatc
tgcctgtccatgtcactccacttcctgatcctctatgtc
gaacccttgccactcatcttccagatcacaccgctgaac
gtgacccagtggctgatggtgctgaaaatctccttgccc
gtgattctcatggatgagacgctcaagtttgtggcccgc
aactacctggaacctggtaaagagtgtgtgcagcctgcc
accaaatcctgctcgttctcggcatgcaccgatgggatt
tcctggccgtttgtgctgctcataatgcccctggtgatc
tgggtctatagcacagacactaactttagcgatatgttc
tggtcttga
other info1 :
Vector: Please Inquire
ncbi gi num :
23272582
ncbi acc num :
BC035588
ncbi mol weight :
109,734 Da
ncbi pathways :
Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93344)
ncbi summary :
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
uniprot summary :
SERCA2: an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described. Protein type: Transporter; EC 3.6.3.8; Membrane protein, multi-pass; Hydrolase; Endoplasmic reticulum; Transporter, ion channel; Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 12q24.11. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane. Molecular Function: calcium ion binding; calcium-transporting ATPase activity; enzyme binding; protein binding. Biological Process: cell adhesion; elevation of endoplasmic reticulum calcium ion concentration; endoplasmic reticulum calcium ion homeostasis; epidermis development; positive regulation of heart rate. Disease: Acrokeratosis Verruciformis; Darier-white Disease
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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