product summary
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company name :
MyBioSource
product type :
cDNA
product name :
NCOA3 cDNA Clone
catalog :
MBS1269963
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1269963
products type :
cDNA Clone
products full name :
NCOA3 cDNA Clone
products short name :
NCOA3
other names :
Homo sapiens nuclear receptor coactivator 3, mRNA; Nuclear receptor coactivator 3; nuclear receptor coactivator 3; nuclear receptor coactivator 3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1
products gene name :
NCOA3
other gene names :
NCOA3; NCOA3; ACTR; AIB1; RAC3; SRC3; pCIP; AIB-1; CTG26; SRC-3; CAGH16; KAT13B; TNRC14; TNRC16; TRAM-1; bHLHe42; AIB1; BHLHE42; RAC3; TRAM1; NCoA-3; AIB-1; pCIP; bHLHe42; RAC-3; SRC-3; TRAM-1
uniprot entry name :
NCOA3_HUMAN
sequence length :
7433
sequence :
ATGAGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGT
GATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGA
CAAGGTCTTACCTGCAGTGGTGAAAAACGGAGACGGGAG
CAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATA
TCTGCCAATCTTAGTGATATTGACAATTTCAATGTCAAA
CCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAG
ATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAAT
GATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGG
CAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTTTA
CTTCAGGCATTGGATGGTTTCCTATTTGTGGTGAATCGA
GACGGAAACATTGTATTTGTATCAGAAAATGTCACACAA
TACCTGCAATATAAGCAAGAGGACCTGGTTAACACAAGT
GTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTT
CTTAAGAATTTACCAAAATCTACAGTTAATGGAGTTTCC
TGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTT
AATTGCCGTATGTTGATGAAAACACCACATGATATTCTG
GAAGACATAAACGCCAGTCCTGAAATGCGCCAGAGATAT
GAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCT
ATGATGGAGGAAGGGGAAGATTTGCAATCTTGTATGATC
TGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTT
CCATCAAACCCTGAGAGCTTTATTACCAGACATGATCTT
TCAGGAAAGGTTGTCAATATAGATACAAATTCACTGAGA
TCCTCCATGAGGCCTGGCTTTGAAGATATAATCCGAAGG
TGTATTCAGAGATTTTTTAGTCTAAATGATGGGCAGTCA
TGGTCCCAGAAACGTCACTATCAAGAAGCTTATCTTAAT
GGCCATGCAGAAACCCCAGTATATCGATTCTCGTTGGCT
GATGGAACTATAGTGACTGCACAGACAAAAAGCAAACTC
TTCCGAAATCCTGTAACAAATGATCGACATGGCTTTGTC
TCAACCCACTTCCTTCAGAGAGAACAGAATGGATATAGA
CCAAACCCAAATCCTGTTGGACAAGGGATTAGACCACCT
ATGGCTGGATGCAACAGTTCGGTAGGCGGCATGAGTATG
TCGCCAAACCAAGGCTTACAGATGCCGAGCAGCAGGGCC
TATGGCTTGGCAGACCCTAGCACCACAGGGCAGATGAGT
GGAGCTAGGTATGGGGGTTCCAGTAACATAGCTTCATTG
ACCCCTGGGCCAGGCATGCAATCACCATCTTCCTACCAG
AACAACAACTATGGGCTCAACATGAGTAGCCCCCCACAT
GGGAGTCCTGGTCTTGCCCCAAACCAGCAGAATATCATG
ATTTCTCCTCGTAATCGTGGGAGTCCAAAGATAGCCTCA
CATCAGTTTTCTCCTGTTGCAGGTGTGCACTCTCCCATG
GCATCTTCTGGCAATACTGGGAACCACAGCTTTTCCAGC
AGCTCTCTCAGTGCCCTGCAAGCCATCAGTGAAGGTGTG
GGGACTTCCCTTTTATCTACTCTGTCATCACCAGGCCCC
AAATTGGATAACTCTCCCAATATGAATATTACCCAACCA
AGTAAAGTAAGCAATCAGGATTCCAAGAGTCCTCTGGGC
TTTTATTGCGACCAAAATCCAGTGGAGAGTTCAATGTGT
CAGTCAAATAGCAGAGATCACCTCAGTGACAAAGAAAGT
AAGGAGAGCAGTGTTGAGGGGGCAGAGAATCAAAGGGGT
CCTTTGGAAAGCAAAGGTCATAAAAAATTACTGCAGTTA
CTTACCTGTTCTTCTGATGACCGGGGTCATTCCTCCTTG
ACCAACTCCCCCCTAGATTCAAGTTGTAAAGAATCTTCT
GTTAGTGTCACCAGCCCCTCTGGAGTCTCCTCCTCTACA
TCTGGAGGAGTATCCTCTACATCCAATATGCATGGGTCA
CTGTTACAAGAGAAGCACCGGATTTTGCACAAGTTGCTG
CAGAATGGGAATTCACCAGCTGAGGTAGCCAAGATTACT
GCAGAAGCCACTGGGAAAGACACCAGCAGTATAACTTCT
TGTGGGGACGGAAATGTTGTCAAGCAGGAGCAGCTAAGT
CCTAAGAAGAAGGAGAATAATGCACTTCTTAGATACCTG
CTGGACAGGGATGATCCTAGTGATGCACTCTCTAAAGAA
CTACAGCCCCAAGTGGAAGGAGTGGATAATAAAATGAGT
CAGTGCACCAGCTCCACCATTCCTAGCTCAAGTCAAGAG
AAAGACCCTAAAATTAAGACAGAGACAAGTGAAGAGGGA
TCTGGAGACTTGGATAATCTAGATGCTATTCTTGGTGAT
CTGACTAGTTCTGACTTTTACAATAATTCCATATCCTCA
AATGGTAGTCATCTGGGGACTAAGCAACAGGTGTTTCAA
GGAACTAATTCTCTGGGTTTGAAAAGTTCACAGTCTGTG
CAGTCTATTCGTCCTCCATATAACCGAGCAGTGTCTCTG
GATAGCCCTGTTTCTGTTGGCTCAAGTCCTCCAGTAAAA
AATATCAGTGCTTTCCCCATGTTACCAAAGCAACCCATG
TTGGGTGGGAATCCAAGAATGATGGATAGTCAGGAAAAT
TATGGCTCAAGTATGGGTGGGCCAAACCGAAATGTGACT
GTGACTCAGACTCCTTCCTCAGGAGACTGGGGCTTACCA
AACTCAAAGGCCGGCAGAATGGAACCTATGAATTCAAAC
TCCATGGGAAGACCAGGAGGAGATTATAATACTTCTTTA
CCCAGACCTGCACTGGGTGGCTCTATTCCCACATTGCCT
CTTCGGTCTAATAGCATACCAGGTGCGAGACCAGTATTG
CAACAGCAGCAGCAGATGCTTCAAATGAGGCCTGGTGAA
ATCCCCATGGGAATGGGGGCTAATCCCTATGGCCAAGCA
GCAGCATCTAACCAACTGGGTTCCTGGCCCGATGGCATG
TTGTCCATGGAACAAGTTTCTCATGGCACTCAAAATAGG
CCTCTTCTTAGGAATTCCCTGGATGATCTTGTTGGGCCA
CCTTCCAACCTGGAAGGCCAGAGTGACGAAAGAGCATTA
TTGGACCAGCTGCACACTCTTCTCAGCAACACAGATGCC
ACAGGCCTGGAAGAAATTGACAGAGCTTTGGGCATTCCT
GAACTTGTCAATCAGGGACAGGCATTAGAGCCCAAACAG
GATGCTTTCCAAGGCCAAGAAGCAGCAGTAATGATGGAT
CAGAAGGCAGGATTATATGGACAGACATACCCAGCACAG
GGGCCTCCAATGCAAGGAGGCTTTCATCTTCAGGGACAA
TCACCATCTTTTAACTCTATGATGAATCAGATGAACCAG
CAAGGCAATTTTCCTCTCCAAGGAATGCACCCACGAGCC
AACATCATGAGACCCCGGACAAACACCCCCAAGCAACTT
AGAATGCAGCTTCAGCAGAGGCTGCAGGGCCAGCAGTTT
TTGAATCAGAGCCGACAGGCACTTGAATTGAAAATGGAA
AACCCTACTGCTGGTGGTGCTGCGGTGATGAGGCCTATG
ATGCAGCCCCAGCAGGGTTTTCTTAATGCTCAAATGGTC
GCCCAACGCAGCAGAGAGCTGCTAAGTCATCACTTCCGA
CAACAGAGGGTGGCTATGATGATGCAGCAGCAGCAGCAG
CAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAG
CAACAGCAACAGCAACAGCAGCAACAGCAGCAAACCCAG
GCCTTCAGCCCACCTCCTAATGTGACTGCTTCCCCCAGC
ATGGATGGGCTTTTGGCAGGACCCACAATGCCACAAGCT
CCTCCGCAACAGTTTCCATATCAACCAAATTATGGAATG
GGACAACAACCAGATCCAGCCTTTGGTCGAGTGTCTAGT
CCTCCCAATGCAATGATGTCGTCAAGAATGGGTCCCTCC
CAGAATCCCATGATGCAACACCCGCAGGCTGCATCCATC
TATCAGTCCTCAGAAATGAAGGGCTGGCCATCAGGAAAT
TTGGCCAGGAACAGCTCCTTTTCCCAGCAGCAGTTTGCC
CACCAGGGGAATCCTGCAGTGTATAGTATGGTGCACATG
AATGGCAGCAGTGGTCACATGGGACAGATGAACATGAAC
CCCATGCCCATGTCTGGCATGCCTATGGGTCCTGATCAG
AAATACTGCTGA
other info1 :
Vector: Please Inquire
ncbi gi num :
111598959
ncbi acc num :
BC119001
ncbi mol weight :
154,892 Da
ncbi pathways :
Androgen Receptor Signaling Pathway (198806); Developmental Biology Pathway (477129); FOXA1 Transcription Factor Network Pathway (137979); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Integrated Breast Cancer Pathway (219801); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544); Retinoic Acid Receptors-mediated Signaling Pathway (138039)
ncbi summary :
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
uniprot summary :
SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described. Protein type: EC 2.3.1.48; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 20q12. Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus. Molecular Function: histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; protein binding; protein N-terminus binding; transcription coactivator activity. Biological Process: intracellular receptor-mediated signaling pathway; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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