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company name :
MyBioSource
product type :
cDNA
product name :
PTPRO cDNA Clone
catalog :
MBS1269792
quantity :
0.01 mg Plasmid + 0.
price :
175 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1269792
products type :
cDNA Clone
products full name :
PTPRO cDNA Clone
products short name :
PTPRO
other names :
Homo sapiens protein tyrosine phosphatase, receptor type, O, mRNA; Receptor-type tyrosine-protein phosphatase O; receptor-type tyrosine-protein phosphatase O; PTP phi; PTPase U2; phosphotyrosine phosphatase U2; glomerular epithelial protein 1; protein tyrosine phosphatase PTP-U2; osteoclastic transmembrane protein-tyrosine phosphatase; protein tyrosine phosphatase, receptor type, O; Glomerular epithelial protein 1; Protein tyrosine phosphatase U2
products gene name :
PTPRO
other gene names :
PTPRO; PTPRO; NPHS6; PTPU2; GLEPP1; PTP-OC; PTP-U2; PTPROT; R-PTP-O; GLEPP1; PTPU2; R-PTP-O; PTP-U2; PTPase U2
uniprot entry name :
PTPRO_HUMAN
sequence length :
5147
sequence :
ATGGGGCACCTGCCCACGGGGATACACGGCGCCCGCCGC
CTCCTGCCTCTGCTCTGGCTCTTTGTGCTGTTCAAGAAT
GCTACAGCTTTCCATGTAACTGTCCAAGATGATAATAAC
ATCGTTGTCTCATTAGAAGCTTCAGACGTCATCAGTCCA
GCATCTGTGTATGTTGTGAAGATAACTGGTGAATCCAAA
AATTATTTCTTCGAATTTGAGGAATTCAACAGCACTTTG
CCTCCTCCTGTTATTTTCAAGGCCAGTTATCATGGCCTT
TATTATATAATCACTCTGGTAGTGGTAAATGGAAATGTG
GTGACCAAGCCATCCAGATCAATCACTGTGTTAACAAAA
CCTCTACCTGTAACCAGTGTTTCCATATATGACTATAAA
CCTTCTCCTGAAACAGGAGTCCTGTTTGAAATACATTAT
CCAGAAAAATATAACGTTTTCACAAGAGTGAACATTAGC
TACTGGGAAGGTAAAGACTTCCGGACAATGCTATATAAA
GATTTCTTTAAGGGAAAAACAGTATTTAATCACTGGCTG
CCAGGAATGTGTTATAGTAATATCACCTTTCAGCTGGTA
TCTGAGGCAACTTTTAATAAAAGTACCCTTGTTGAGTAC
AGTGGTGTCAGTCACGAACCCAAACAGCACAGAACTGCC
CCTTATCCACCTCAAAATATTTCCGTTCGTATCGTAAAC
TTGAACAAAAACAACTGGGAAGAACAGAGTGGCAATTTC
CCAGAAGAATCCTTCATGAGATCACAAGATACAATAGGA
AAAGAAAAACTCTTCCATTTTACAGAAGAAACCCCTGAA
ATTCCCTCGGGCAACATTTCTTCCGGTTGGCCTGATTTT
AATAGCAGTGACTATGAAACTACGTCTCAGCCATATTGG
TGGGACAGTGCATCTGCAGCTCCTGAAAGTGAAGATGAA
TTTGTCAGCGTACTTCCCATGGAATACGAAAATAACAGT
ACACTCAGTGAGACAGAGAAGTCAACATCAGGCTCTTTC
TCCTTTTTCCCTGTGCAAATGATATTGACCTGGTTACCA
CCCAAACCACCCACTGCTTTTGATGGGTTCCATATCCAT
ATTGAACGAGAAGAGAACTTTACTGAATATTTGATGGTG
GATGAAGAAGCACATGAATTTGTTGCAGAACTGAAGGAA
CCTGGGAAATATAAGTTATCTGTGACAACCTTTAGTTCC
TCAGGATCTTGTGAAACTCGAAAAAGTCAGTCAGCAAAA
TCACTCAGCTTTTATATCAGTCCTTCAGGAGAGTGGATT
GAAGAACTGACCGAGAAGCCGCAGCACGTGAGTGTCCAC
GTTTTAAGCTCAACCACTGCCTTGATGTCCTGGACATCT
TCCCAAGAGAACTACAACAGCACCATTGTGTCTGTGGTG
TCGCTGACCTGCCAGAAACAAAAGGAGAGCCAGAGGCTT
GAAAAGCAGTACTGCACTCAGGTGAACTCAAGCAAACCT
ATTATTGAAAATCTGGTTCCTGGTGCCCAGTACCAGGTT
GTAATATACCTAAGGAAAGGCCCTTTGATTGGACCACCT
TCAGATCCTGTGACATTTGCTATTGTTCCCACAGGAATA
AAGGATTTAATGCTCTATCCTTTGGGTCCTACGGCCGTG
GTTCTGAGCTGGACCAGACCTTATTTAGGCGTGTTCAGA
AAATACGTGGTTGAAATGTTTTATTTCAACCCTGCTACA
ATGACATCAGAATGGGGCACCTGCCCACGGGGATACACG
GCGCCCGCCGCCTCCTGCCTCTGCTCTGGCTCTTTGTGC
TGTTCAAGAATGCTACAGCTTTCCATGTAACTGTCCAAG
ATGATAATAACATCGTTGTCTCATTAGAAGCTTCAGACG
TCATCAGTCCAGCATCTGTGTATGTTGTGAAGATAACTG
GTGAATCCAAAAATTATTTCTTCGAATTTGAGGAATTCA
ACAGCACTTTGCCTCCTCCTGTTATTTTCAAGGCCAGTT
ATCATGGCCTTTATTATATAATCACTCTGGTAGTGGTAA
ATGGAAATGTGGTGACCAAGCCATCCAGATCAATCACTG
TGTTAACAAAACCTCTACCTGTAACCAGTGTTTCCATAT
ATGACTATAAACCTTCTCCTGAAACAGGAGTCCTGTTTG
AAATACATTATCCAGAAAAATATAACGTTTTCACAAGAG
TGAACATTAGCTACTGGGAAGGTAAAGACTTCCGGACAA
TGCTATATAAAGATTTCTTTAAGGGAAAAACAGTATTTA
ATCACTGGCTGCCAGGAATGTGTTATAGTAATATCACCT
TTCAGCTGGTATCTGAGGCAACTTTTAATAAAAGTACCC
TTGTTGAGTACAGTGGTGTCAGTCACGAACCCAAACAGC
ACAGAACTGCCCCTTATCCACCTCAAAATATTTCCGTTC
GTATCGTAAACTTGAACAAAAACAACTGGGAAGAACAGA
GTGGCAATTTCCCAGAAGAATCCTTCATGAGATCACAAG
ATACAATAGGAAAAGAAAAACTCTTCCATTTTACAGAAG
AAACCCCTGAAATTCCCTCGGGCAACATTTCTTCCGGTT
GGCCTGATTTTAATAGCAGTGACTATGAAACTACGTCTC
AGCCATATTGGTGGGACAGTGCATCTGCAGCTCCTGAAA
GTGAAGATGAATTTGTCAGCGTACTTCCCATGGAATACG
AAAATAACAGTACACTCAGTGAGACAGAGAAGTCAACAT
CAGGCTCTTTCTCCTTTTTCCCTGTGCAAATGATATTGA
CCTGGTTACCACCCAAACCACCCACTGCTTTTGATGGGT
TCCATATCCATATTGAACGAGAAGAGAACTTTACTGAAT
ATTTGATGGTGGATGAAGAAGCACATGAATTTGTTGCAG
AACTGAAGGAACCTGGGAAATATAAGTTATCTGTGACAA
CCTTTAGTTCCTCAGGATCTTGTGAAACTCGAAAAAGTC
AGTCAGCAAAATCACTCAGCTTTTATATCAGTCCTTCAG
GAGAGTGGATTGAAGAACTGACCGAGAAGCCGCAGCACG
TGAGTGTCCACGTTTTAAGCTCAACCACTGCCTTGATGT
CCTGGACATCTTCCCAAGAGAACTACAACAGCACCATTG
TGTCTGTGGTGTCGCTGACCTGCCAGAAACAAAAGGAGA
GCCAGAGGCTTGAAAAGCAGTACTGCACTCAGGTGAACT
CAAGCAAACCTATTATTGAAAATCTGGTTCCTGGTGCCC
AGTACCAGGTTGTAATATACCTAAGGAAAGGCCCTTTGA
TTGGACCACCTTCAGATCCTGTGACATTTGCTATTGTTC
CCACAGGAATAAAGGATTTAATGCTCTATCCTTTGGGTC
CTACGGCCGTGGTTCTGAGCTGGACCAGACCTTATTTAG
GCGTGTTCAGAAAATACGTGGTTGAAATGTTTTATTTCA
ACCCTGCTACAATGACATCAGA
other info1 :
Vector: Please Inquire. Accession Number: BC126201. cDNA Size: 3651. Recombination site: attL1, attL2. Gene ID: 5800
products description :
Homo sapiens protein tyrosine phosphatase, receptor type, O, mRNA (cDNA clone MGC:161479 IMAGE:8991917), complete cds.
ncbi gi num :
116496640
ncbi acc num :
BC126201
uniprot acc num :
Q16827
ncbi mol weight :
138,344 Da
ncbi pathways :
Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway (138068)
ncbi summary :
This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
uniprot summary :
PTPRO: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6). NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; EC 3.1.3.48; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.3-p13.2 12p13-p12. Cellular Component: neuron projection; growth cone; lamellipodium; integral to plasma membrane; axon; apical plasma membrane; integral to membrane; plasma membrane; dendritic spine; lateral plasma membrane. Molecular Function: Wnt-protein binding; protein binding; protein homodimerization activity; phosphoric monoester hydrolase activity; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity. Biological Process: lamellipodium biogenesis; axon guidance; monocyte chemotaxis; regulation of glomerular filtration; negative regulation of glomerular filtration; cell morphogenesis; protein amino acid dephosphorylation; glomerulus development. Disease: Nephrotic Syndrome, Type 6
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
175 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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