product summary
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company name :
MyBioSource
product type :
cDNA
product name :
HPSE2 cDNA Clone
catalog :
MBS1268922
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1268922
products type :
cDNA Clone
products full name :
HPSE2 cDNA Clone
products short name :
HPSE2
other names :
Homo sapiens heparanase 2, mRNA; Inactive heparanase-2; inactive heparanase-2; heparanase 2 (inactive)
products gene name :
HPSE2
other gene names :
HPSE2; HPSE2; UFS; HPA2; HPR2; UFS1; HPA2; Hpa2
uniprot entry name :
HPSE2_HUMAN
sequence length :
1927
sequence :
ATGAGGGTGCTTTGTGCCTTCCCTGAAGCCATGCCCTCC
AGCAACTCCCGCCCCCCCGCGTGCCTAGCCCCGGGGGCT
CTCTACTTGGCTCTGTTGCTCCATCTCTCCCTTTCCTCC
CAGGCTGGAGACAGGAGACCCTTGCCTGTAGACAGAGCT
GCAGGTTTGAAGGAAAAGACCCTGATTCTACTTGATGTG
AGCACCAAGAACCCAGTCAGGACAGTCAATGAGAACTTC
CTCTCTCTGCAGCTGGATCCGTCCATCATTCATGATGGC
TGGCTCGATTTCCTAAGCTCCAAGCGCTTGGTGACCCTG
GCCCGGGGACTTTCGCCCGCCTTTCTGCGCTTCGGGGGC
AAAAGGACCGACTTCCTGCAGTTCCAGAACCTGAGGAAC
CCGGCGAAAAGCCGCGGGGGCCCGGGCCCGGATTACTAT
CTCAAAAACTATGAGGATGACATTGTTCGAAGTGATGTT
GCCTTAGATAAACAGAAAGGCTGCAAGATTGCCCAGCAC
CCTGATGTTATGCTGGAGCTCCAAAGGGAGAAGGCAGCT
CAGATGCATCTGGTTCTTCTAAAGGAGCAATTCTCCAAT
ACTTACAGTAATCTCATATTAACAGCCAGGTCTCTAGAC
AAACTTTATAACTTTGCTGATTGCTCTGGACTCCACCTG
ATATTTGCTCTAAATGCACTGCGTCGTAATCCCAATAAC
TCCTGGAACAGTTCTAGTGCCCTGAGTCTGTTGAAGTAC
AGCGCCAGCAAAAAGTACAACATTTCTTGGGAACTGGGT
AATGAGCCAAATAACTATCGGACCATGCATGGCCGGGCA
GTAAATGGCAGCCAGTTGGGAAAGGATTACATCCAGCTG
AAGAGCCTGTTGCAGCCCATCCGGATTTATTCCAGAGCC
AGCTTATATGGCCCTAATATTGGGCGGCCGAGGAAGAAT
GTCATCGCCCTCCTAGATGGATTCATGAAGGTGGCAGGA
AGTACAGTAGATGCAGTTACCTGGCAACATTGCTACATT
GATGGCCGGGTGGTCAAGGTGATGGACTTCCTGAAAACT
CGCCTGTTAGACACACTCTCTGACCAGATTAGGAAAATT
CAGAAAGTGGTTAATACATACACTCCAGGAAAGAAGATT
TGGCTTGAAGGTGTGGTGACCACCTCAGCTGGAGGCACA
AACAATCTATCCGATTCCTATGCTGCAGGATTCTTATGG
TTGAACACTTTAGGAATGCTGGCCAATCAGGGCATTGAT
GTCGTGATACGGCACTCATTTTTTGACCATGGATACAAT
CACCTCGTGGACCAGAATTTTAACCCATTACCAGACTAC
TGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAA
GTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCA
CGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTAT
GCTCACTGCACAAACCACCACAACCACAACTACGTTCGT
GGGTCCATTACACTTTTTATCATCAACTTGCATCGATCA
AGAAAGAAAATCAAGCTGACTGGGACTCTCAGAGACAAG
CTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAG
GGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCC
TTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAG
CCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCT
CCAGTCACCATGGGCTTTTTTGTGGTCAAGAATGTCAAT
GCTTTGGCCTGCCGCTACCGATAA
other info1 :
Vector: Please Inquire
ncbi gi num :
85662623
ncbi acc num :
BC112356
ncbi mol weight :
53,917 Da
ncbi pathways :
Disease Pathway (530764); Glycosaminoglycan Degradation Pathway (82981); Glycosaminoglycan Degradation Pathway (355); Glycosaminoglycan Metabolism Pathway (645297); HS-GAG Degradation Pathway (645307); Heparan Sulfate Degradation Pathway (413377); Heparan Sulfate Degradation Pathway (468270); Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway (645304); MPS I - Hurler Syndrome Pathway (685537); MPS II - Hunter Syndrome Pathway (685538)
ncbi summary :
This gene encodes a heparanase enzyme. The encoded protein is a endoglycosidase that degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface. This protein may be involved in biological processes involving remodeling of the extracellular matrix including angiogenesis and tumor progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
uniprot summary :
HPSE2: Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Defects in HPSE2 are the cause of urofacial syndrome (UFS). A rare autosomal recessive characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. Belongs to the glycosyl hydrolase 79 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.2.-.-; Hydrolase; Glycan Metabolism - glycosaminoglycan degradation. Chromosomal Location of Human Ortholog: 10q23-q24. Cellular Component: intracellular; plasma membrane; proteinaceous extracellular matrix. Molecular Function: heparan sulfate proteoglycan binding; heparanase activity. Biological Process: extracellular matrix organization and biogenesis; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process. Disease: Urofacial Syndrome 1
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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