IFNB1 Polyclonal Antibody | MyBioSource MBS126854 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IFNB1 Polyclonal Antibody

catalog :

MBS126854

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using IFNB1 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

product information

catalog number :

MBS126854

products type :

Antibody

products full name :

IFNB1 Polyclonal Antibody

products short name :

[IFNB1]

products name syn :

[IFNB1; IFB; IFF; IFNB; MGC96956]

other names :

[Interferon beta; Interferon beta; interferon beta; IFN-beta; fibroblast interferon; interferon, beta 1, fibroblast; Fibroblast interferon]

products gene name :

[IFNB1]

other gene names :

[IFNB1; IFNB1; IFB; IFF; IFNB; IFB; IFNB; IFN-beta]

uniprot entry name :

IFNB_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

187

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C. Avoid freeze / thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200

image1 heading :

Western Blot (WB)

other info1 :

Species: Human. Immunogen: Recombinant Protein

other info2 :

Immunogen: Recombinant protein of human IFNB1. Calculated Molecular Weight: 22kDa. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

products categories :

Polyclonal

products description :

The genes encoding type I interferons (IFNs), which include 14 IFN-¥ genes, one IFN-ˆ« gene, one IFN-w (also known as IFN-¥ II1) gene, and a number of IFN-w pseudogenes, are clustered on human chromosome 9. Interferons-¥ and -ˆ« are cytokines that are widely known to induce potent antiviral activity. IFN-¥ and -ˆ« exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-¥, IFN-ˆ« or IFN-©, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-¥R) interacts with IFN-¥, IFN-ˆ« and IFN-w, and seems to be a multisubunit receptor.

ncbi gi num :

124469

ncbi acc num :

P01574.1

uniprot acc num :

P01574

ncbi mol weight :

187

ncbi pathways :

Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response Pathway (198794); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833)

uniprot summary :

IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 9p21. Cellular Component: extracellular space; extracellular region. Molecular Function: interferon-alpha/beta receptor binding; cytokine activity. Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

275

size3 :

0.2 mL

price3 :

430

more info or order :

MyBioSource product webpage