BAG3 cDNA Clone | MyBioSource MBS1268103 product information

product summary

company name :

MyBioSource

product type :

cDNA

product name :

BAG3 cDNA Clone

catalog :

MBS1268103

quantity :

0.01 mg Plasmid + 0.

price :

175 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS1268103

products type :

cDNA Clone

products full name :

BAG3 cDNA Clone

products short name :

BAG3

other names :

Homo sapiens BCL2-associated athanogene 3, mRNA; BAG family molecular chaperone regulator 3; BAG family molecular chaperone regulator 3; docking protein CAIR-1; BCL2-binding athanogene 3; bcl-2-binding protein Bis; BCL2-associated athanogene 3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1

products gene name :

BAG3

other gene names :

BAG3; BAG3; BIS; BAG-3; CAIR-1; BIS; BAG-3

uniprot entry name :

BAG3_HUMAN

sequence length :

2586

sequence :

ATGAGCGCCGCCACCCACTCGCCCATGATGCAGGTGGCG
TCCGGCAACGGTGACCGCGACCCTTTGCCCCCCGGATGG
GAGATCAAGATCGACCCGCAGACCGGCTGGCCCTTCTTC
GTGGACCACAACAGCCGCACCACTACGTGGAACGACCCG
CGCGTGCCCTCTGAGGGCCCCAAGGAGACTCCATCCTCT
GCCAATGGCCCTTCCCGGGAGGGCTCTAGGCTGCCGCCT
GCTAGGGAAGGCCACCCTGTGTACCCCCAGCTCCGACCA
GGCTACATTCCCATTCCTGTGCTCCATGAAGGCGCTGAG
AACCGGCAGGTGCACCCTTTCCATGTCTATCCCCAGCCT
GGGATGCAGCGATTCCGAACTGAGGCGGCAGCAGCGGCT
CCTCAGAGGTCCCAGTCACCTCTGCGGGGCATGCCAGAA
ACCACTCAGCCAGATAAACAGTGTGGACAGGTGGCAGCG
GCGGCGGCAGCCCAGCCCCCAGCCTCCCACGGACCTGAG
CGGTCCCAGTCTCCAGCTGCCTCTGACTGCTCATCCTCA
TCCTCCTCGGCCAGCCTGCCTTCCTCCGGCAGGAGCAGC
CTGGGCAGTCACCAGCTCCCGCGGGGGTACATCTCCATT
CCGGTGATACACGAGCAGAACGTTACCCGGCCAGCAGCC
CAGCCCTCCTTCCACCAAGCCCAGAAGACGCACTACCCA
GCGCAGCAGGGGGAGTACCAGACCCACCAGCCTGTGTAC
CACAAGATCCAGGGGGATGACTGGGAGCCCCGGCCCCTG
CGGGCGGCATCCCCGTTCAGGTCATCTGTCCAGGGTGCA
TCGAGCCGGGAGGGCTCACCAGCCAGGAGCAGCACGCCA
CTCCACTCCCCCTCGCCCATCCGTGTGCACACCGTGGTC
GACAGGCCTCAGCAGCCCATGACCCATCGAGAAACTGCA
CCTGTTTCCCAGCCTGAAAACAAACCAGAAAGTAAGCCA
GGCCCAGTTGGACCAGAACTCCCTCCTGGACACATCCCA
ATTCAAGTGATCCGCAAAGAGGTGGATTCTAAACCTGTT
TCCCAGAAGCCCCCACCTCCCTCTGAGAAGGTAGAGGTG
AAAGTTCCCCCTGCTCCAGTTCCTTGTCCTCCTCCCAGC
CCTGGCCCTTCTGCTGTCCCCTCTTCCCCCAAGAGTGTG
GCTACAGAAGAGAGGGCAGCCCCCAGCACTGCCCCTGCA
GAAGCTACACCTCCAAAACCAGGAGAAGCCGAGGCTCCC
CCAAAACATCCAGGAGTGCTGAAAGTGGAAGCCATCCTG
GAGAAGGTACAGGGGCTGGAGCAGGCTGTAGACAACTTT
GAAGGCAAGAAGACTGACAAAAAGTACCTGATGATCGAA
GAGTATTTGACCAAAGAGCTGCTGGCCCTGGATTCAGTG
GACCCCGAGGGACGAGCCGATGTGCGTCAGGCCAGGAGA
GACGGTGTCAGGAAGGTTCAGACCATCTTGGAAAAACTT
GAACAGAAAGCCATTGATGTCCCAGGTCAAGTCCAGGTC
TATGAACTCCAGCCCAGCAACCTTGAAGCAGATCAGCCA
CTGCAGGCAATCATGGAGATGGGTGCCGTGGCAGCAGAC
AAGGGCAAGAAAAATGCTGGAAATGCAGAAGATCCCCAC
ACAGAAACCCAGCAGCCAGAAGCCACAGCAGCAGCGACT
TCAAACCCCAGCAGCATGACAGACACCCCTGGTAACCCA
GCAGCACCGTAG

other info1 :

Accession Number: BC006418. cDNA Size: cDNA Size. Recombination site: attL1, attL2. Gene ID: 9531. Vector: Please Inquire

ncbi gi num :

13623600

ncbi acc num :

BC006418

uniprot acc num :

O95817

ncbi mol weight :

61,595 Da

ncbi pathways :

Apoptosis Modulation And Signaling Pathway (198822)

ncbi summary :

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

uniprot summary :

BAG3: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity. Defects in BAG3 are the cause of myopathy myofibrillar type 6 (MFM6). A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. Defects in BAG3 are the cause of cardiomyopathy dilated type 1HH (CMD1HH). CMD1HH is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 10q25.2-q26.2. Cellular Component: neuron projection; cytoplasm; plasma membrane; cytosol; Z disc. Molecular Function: protein binding; chaperone binding; protein complex binding. Biological Process: protein stabilization; induction of apoptosis via death domain receptors; protein folding; spinal cord development; brain development; negative regulation of apoptosis. Disease: Myopathy, Myofibrillar, 6; Cardiomyopathy, Dilated, 1hh

size1 :

0.01 mg Plasmid + 0.2 mL Glycerol-Stock

price1 :

175 USD

more info or order :

MyBioSource product webpage