product summary
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company name :
MyBioSource
product type :
cDNA
product name :
WWP1 cDNA Clone
catalog :
MBS1267912
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1267912
products type :
cDNA Clone
products full name :
WWP1 cDNA Clone
products short name :
WWP1
other names :
Homo sapiens WW domain containing E3 ubiquitin protein ligase 1, mRNA; NEDD4-like E3 ubiquitin-protein ligase WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; WW domain containing E3 ubiquitin protein ligase 1; Atrophin-1-interacting protein 5; AIP5; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
products gene name :
WWP1
other gene names :
WWP1; WWP1; AIP5; Tiul1; hSDRP1; AIP5; Tiul1
uniprot entry name :
WWP1_HUMAN
sequence length :
3855
sequence :
atggccactgcttcaccaaggtctgatactagtaataac
cacagtggaaggttgcagttacaggtaactgtttctagt
gccaaacttaaaagaaaaaagaactggttcggaacagca
atatatacagaagtagttgtagatggagaaattacgaaa
acagcaaaatccagtagttcttctaatccaaaatgggat
gaacagctaactgtaaatgttacgccacagactacattg
gaatttcaagtttggagccatcgcactttaaaagcagat
gctttattaggaaaagcaacgatagatttgaaacaagct
ctgttgatacacaatagaaaattggaaagagtgaaagaa
caattaaaactttccttggaaaacaagaatggcatagca
caaactggtgaattgacagttgtgcttgatggattggtg
attgagcaagaaaatataacaaactgcagctcatctcca
accatagaaatacaggaaaatggtgatgccttacatgaa
aatggagagccttcagcaaggacaactgccaggttggct
gttgaaggcacgaatggaatagataatcatgtacctaca
agcactctagtccaaaactcatgctgctcgtatgtagtt
aatggagacaacacaccttcatctccgtctcaggttgct
gccagacccaaaaatacaccagctccaaaaccactcgca
tctgagcctgccgatgacactgttaatggagaatcatcc
tcatttgcaccaactgataatgcgtctgtcacgggtact
ccagtagtgtctgaagaaaatgccttgtctccaaattgc
actagtactactgttgaagatcctccagttcaagaaata
ctgacttcctcagaaaacaatgaatgtattccttctacc
agtgcagaattggaatctgaagctagaagtatattagag
cctgacacctctaattctagaagtagttctgcttttgaa
gcagccaaatcaagacagccagatgggtgtatggatcct
gtacggcagcagtctgggaatgccaacacagaaaccttg
ccatcagggtgggaacaaagaaaagatcctcatggtaga
acctattatgtggatcataatactcgaactaccacatgg
gagagaccacaacctttacctccaggttgggaaagaaga
gttgatgatcgtagaagagtttattatgtggatcataac
accagaacaacaacgtggcagcggcctaccatggaatct
gtccgaaattttgaacagtggcaatctcagcggaaccaa
ttgcagggagctatgcaacagtttaaccaacgatacctc
tattcggcttcaatgttagctgcagaaaatgacccttat
ggacctttgccaccaggctgggaaaaaagagtggattca
acagacagggtttactttgtgaatcataacacaaaaaca
acccagtgggaagatccaagaactcaaggcttacagaat
gaagaacccctgccagaaggctgggaaattagatatact
cgtgaaggtgtaaggtactttgttgatcataacacaaga
acaacaacattcaaagatcctcgcaatgggaagtcatct
gtaactaaaggtggtccacaaattgcttatgaacgcggc
tttaggtggaagcttgctcacttccgttatttgtgccag
tctaatgcactacctagtcatgtaaagatcaatgtgtcc
cggcagacattgtttgaagattccttccaacagattatg
gcattaaaaccctatgacttgaggaggcgcttatatgta
atatttagaggagaagaaggacttgattatggtggccta
gcgagagaatggtttttcttgctttcacatgaagttttg
aacccaatgtattgcttatttgagtatgcgggcaagaac
aactattgtctgcagataaatccagcatcaaccattaat
ccagaccatctttcatacttctgtttcattggtcgtttt
attgccatggcactatttcatggaaagtttatcgatact
ggtttctctttaccattctacaagcgtatgttaagtaaa
aaacttactattaaggatttggaatctattgatactgaa
ttttataactcccttatctggataagagataacaacatt
gaagaatgtggcttagaaatgtacttttctgttgacatg
gagattttgggaaaagttacttcacatgacctgaagttg
ggaggttccaatattctggtgactgaggagaacaaagat
gaatatattggtttaatgacagaatggcgtttttctcga
ggagtacaagaacagaccaaagctttccttgatggtttt
aatgaagttgttcctcttcagtggctacagtacttcgat
gaaaaagaattagaggttatgttgtgtggcatgcaggag
gttgacttggcagattggcagagaaatactgtttatcga
cattatacaagaaacagcaagcaaatcatttggttttgg
cagtttgtgaaagagacagacaatgaagtaagaatgcga
ctattgcagttcgtcactggaacctgccgtttacctcta
ggaggatttgctgagctcatgggaagtaatgggcctcaa
aagttttgcattgaaaaagttggcaaagacacttggtta
ccaagaagccatacatgttttaatcgcttggatctacca
ccatataagagttatgaacaactaaaggaaaaacttctt
tttgcaatagaagagacagagggatttggacaagaatga
other info1 :
Vector: Please Inquire
ncbi gi num :
23271280
ncbi acc num :
BC036065
ncbi mol weight :
Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Downregulation Of ERBB4 Signaling Pathway (530745); Endocytosis Pathway (102279); Endocytosis Pathway (102181); ErbB4 Signaling Events Pathway (137991); Immune System Pathway (106386); Ion Channel Transport Pathway (187193); Signal Transduction Pathway (477114)
ncbi summary :
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
uniprot summary :
WWP1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. 6 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ligase. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: protein binding; ubiquitin-protein ligase activity. Biological Process: entry of virus into host cell; negative regulation of transcription, DNA-dependent; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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