KPNA1 Polyclonal Antibody | MyBioSource MBS126781 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

KPNA1 Polyclonal Antibody

catalog :

MBS126781

quantity :

0.05 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS126781

products type :

Antibody

products full name :

KPNA1 Polyclonal Antibody

products short name :

KPNA1

products name syn :

RCH2; SRP1; IPOA5; NPI-1

other names :

Importin subunit alpha-5; Importin subunit alpha-5; importin subunit alpha-5; SRP1-beta; importin alpha 5; importin-alpha-S1; RAG cohort protein 2; importin subunit alpha-1; nucleoprotein interactor 1; karyopherin subunit alpha-1; recombination activating gene cohort 2; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-betaImportin subunit alpha-5, N-terminally processed

products gene name :

KPNA1

other gene names :

KPNA1; KPNA1; RCH2; SRP1; IPOA5; NPI-1; RCH2; NPI-1

uniprot entry name :

IMA5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

538

purity :

Affinity Purification

concentration :

1mg/ml

storage stability :

Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200

other info1 :

Species: Human. Immunogen: Recombinant Protein

other info2 :

Immunogen: Recombinant protein of human KPNA1. Calculated Molecular Weight: 60kDa

products categories :

Polyclonal

products description :

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

ncbi gi num :

296439328

ncbi acc num :

P52294.3

uniprot acc num :

P52294

ncbi mol weight :

538

ncbi pathways :

Activation Of DNA Fragmentation Factor Pathway (105683); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Apoptosis Pathway (105648); Apoptosis Induced DNA Fragmentation Pathway (105682); Apoptotic Execution Phase Pathway (105677); Class I PI3K Signaling Events Mediated By Akt Pathway (138020); Cytokine Signaling In Immune System Pathway (366171); Disease Pathway (530764); Early Phase Of HIV Life Cycle Pathway (105985); HIV Infection Pathway (105983)

ncbi summary :

uniprot summary :

KPNA1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Belongs to the importin alpha family. Protein type: Nuclear import; Karyopherin; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 3q21. Cellular Component: nucleoplasm; dendrite; cytoplasm; nuclear pore; cytosol; nucleus. Molecular Function: protein binding; nuclear localization sequence binding; protein transporter activity. Biological Process: viral reproduction; positive regulation of protein import into nucleus; apoptosis; regulation of DNA recombination; cytokine and chemokine mediated signaling pathway; DNA fragmentation during apoptosis; NLS-bearing substrate import into nucleus; viral infectious cycle; cell structure disassembly during apoptosis

size1 :

0.05 mL

price1 :

230 USD

size2 :

0.1 mL

price2 :

305

size3 :

0.2 mL

price3 :

460

more info or order :

MyBioSource product webpage