catalog number :
MBS1267205
products type :
cDNA Clone
products full name :
MAS1 cDNA Clone
products short name :
MAS1
other names :
Homo sapiens MAS1 oncogene, mRNA; Proto-oncogene Mas; proto-oncogene Mas; MAS1 oncogene
products gene name :
MAS1
other gene names :
MAS1; MAS1; MAS; MAS
uniprot entry name :
MAS_HUMAN
sequence :
ATGGATGGGTCAAACGTGACATCATTTGTTGTTGAGGAA
CCCACGAACATCTCAACTGGCAGGAACGCCTCAGTCGGG
AATGCACATCGGCAAATCCCCATCGTGCACTGGGTCATT
ATGAGCATCTCCCCAGTGGGGTTTGTTGAGAATGGGATT
CTCCTCTGGTTCCTGTGCTTCCGGATGAGAAGAAATCCC
TTCACTGTCTACATCACCCACCTGTCTATCGCAGACATC
TCACTGCTCTTCTGTATTTTCATCTTGTCTATCGACTAT
GCTTTAGATTATGAGCTTTCTTCTGGCCATTACTACACA
ATTGTCACATTATCAGTGACTTTTCTGTTTGGCTACAAC
ACGGGCCTCTATCTGCTGACGGCCATTAGTGTGGAGAGG
TGCCTGTCAGTCCTTTACCCCATCTGGTACCGATGCCAT
CGCCCCAAGTACCAGTCGGCATTGGTCTGTGCCCTTCTG
TGGGCTCTTTCTTGCTTGGTGACCACCATGGAGTATGTC
ATGTGCATCGACAGAGAAGAAGAGAGTCACTCTCGGAAT
GACTGCCGAGCAGTCATCATCTTTATAGCCATCCTGAGC
TTCCTGGTCTTCACGCCCCTCATGCTGGTGTCCAGCACC
ATCTTGGTCGTGAAGATCCGGAAGAACACGTGGGCTTCC
CATTCCTCCAAGCTTTACATAGTCATCATGGTCACCATC
ATTATATTCCTCATCTTCGCTATGCCCATGAGACTCCTT
TACCTGCTGTACTATGAGTATTGGTCGACCTTTGGGAAC
CTACACCACATTTCCCTGCTCTTCTCCACAATCAACAGT
AGCGCCAACCCTTTCATTTACTTCTTTGTGGGAAGCAGT
AAGAAGAAGAGATTCAAGGAGTCCTTAAAAGTTGTTCTG
ACCAGGGCTTTCAAAGATGAAATGCAACCTCGGCGCCAG
AAAGACAATTGTAATACGGTCACAGTTGAGACTGTCGTC
TAA
other info1 :
Vector: Please Inquire. Gene ID: 4142. recombination site: attL1, attL2. cDNA Size: 978. Accession Number: BC069581
ncbi mol weight :
37,465 Da
ncbi pathways :
ACE Inhibitor Pathway (198763); GPCRs, Class A Rhodopsin-like Pathway (198886); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486)
ncbi summary :
This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
uniprot summary :
MAS1: Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Oncoprotein. Chromosomal Location of Human Ortholog: 6q25.3-q26. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; angiotensin type II receptor activity; peptide hormone binding; peptide binding; angiotensin receptor activity. Biological Process: response to drug; anatomical structure morphogenesis; hippocampus development; male gonad development; activation of NF-kappaB-inducing kinase; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; regulation of inflammatory response; spermatogenesis; response to activity; positive regulation of DNA replication
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock