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company name :
MyBioSource
product type :
cDNA
product name :
SRD5A2 cDNA Clone
catalog :
MBS1267170
quantity :
0.01 mg Plasmid + 0.
price :
165 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS1267170
products type :
cDNA Clone
products full name :
SRD5A2 cDNA Clone
products short name :
SRD5A2
other names :
Homo sapiens steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2), mRNA; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; steroid 5 alpha-reductase 2; 5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase
products gene name :
SRD5A2
other gene names :
SRD5A2; SRD5A2; S5AR 2
uniprot entry name :
S5A2_HUMAN
sequence length :
1168
sequence :
ATGCAGGTTCAGTGCCAGCAGAGCCCAGTGCTGGCAGGC
AGCGCCACTTTGGTCGCCCTTGGGGCACTGGCCTTGTAC
GTCGCGAAGCCCTCCGGCTACGGGAAGCACACGGAGAGC
CTGAAGCCGGCGGCTACCCGCCTGCCAGCCCGCGCCGCC
TGGTTCCTGCAGGAGCTGCCTTCCTTCGCGGTGCCCGCG
GGGATCCTCGCCCGGCAGCCCCTCTCCCTCTTCGGGCCA
CCTGGGACGGTACTTCTGGGCCTCTTCTGCCTACATTAC
TTCCACAGGACATTTGTGTACTCACTGCTCAATCGAGGG
AGGCCTTATCCAGCTATACTCATTCTCAGAGGCACTGCC
TTCTGCACTGGAAATGGAGTCCTTCAAGGCTACTATCTG
ATTTACTGTGCTGAATACCCTGATGGGTGGTACACAGAC
ATACGGTTTAGCTTGGGTGTCTTCTTATTTATTTTGGGA
ATGGGAATAAACATTCATAGTGACTATATATTGCGCCAG
CTCAGGAAGCCTGGAGAAATCAGCTACAGGATTCCACAA
GGTGGCTTGTTTACGTATGTTTCTGGAGCCAATTTCCTC
GGTGAGATCATTGAATGGATCGGCTATGCCCTGGCCACT
TGGTCCCTCCCAGCACTTGCATTTGCATTTTTCTCACTT
TGTTTCCTTGGGCTGCGAGCTTTTCACCACCATAGGTTC
TACCTCAAGATGTTTGAGGACTACCCCAAATCTCGGAAA
GCCCTTATTCCATTCATCTTTTAA
other info1 :
Vector: Please Inquire
ncbi gi num :
85567677
ncbi acc num :
BC112252
ncbi mol weight :
28,393 Da
ncbi pathways :
Androgen Biosynthesis Pathway (106154); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Metabolism Of Steroid Hormones And Vitamin D Pathway (106150); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Steroid Hormone Biosynthesis Pathway (82940); Steroid Hormone Biosynthesis Pathway (301); Androgen Biosynthesis Pathway (545302)
ncbi summary :
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
uniprot summary :
SRD5A2: Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH). A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Belongs to the steroid 5-alpha reductase family. Protein type: Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; EC 1.3.1.22. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: endoplasmic reticulum membrane. Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; sterol 5-alpha reductase activity. Biological Process: androgen biosynthetic process; androgen metabolic process; cell-cell signaling; male gonad development. Disease: Pseudovaginal Perineoscrotal Hypospadias
size1 :
0.01 mg Plasmid + 0.2 mL Glycerol-Stock
price1 :
165 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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