catalog number :
MBS1265501
products type :
Recombinant Protein
products full name :
Recombinant Mouse Thrombospondin-2
products short name :
Thrombospondin-2
other names :
thrombospondin-2; Thrombospondin-2; thrombospondin-2; thrombospondin 2
products gene name :
Thbs2
other gene names :
Thbs2; Thbs2; TSP2; Thbs-2; Tsp2
uniprot entry name :
TSP2_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
19-232
sequence :
GDHVKDTSFDLFSISNINRKTIGAKQFRGPDPGVPAYRF
VRFDYIPPVNTDDLNRIVKLARRKEGFFLTAQLKQDRKS
RGTLLVLEGPGTSQRQFEIVSNGPGDTLDLNYWVEGNQH
TNFLEDVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVT
LEEPFYEQLEVDRSRMYVAKGASRESHFRGLLQNVHLVF
ADSVEDILSKKGCQHSQGA
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products description :
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
products references :
Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.Laherty C.D., O'Rourke K., Wolf F.W., Katz R., Seldin M.F., Dixit V.M.J. Biol. Chem. 267:3274-3281(1992)
Genomic sequence analysis in the mouse t-complex region.Brathwaite M., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.A second, expressed thrombospondin gene (Thbs2)
exists in the mouse genome.Bornstein P., O'Rourke K., Wikstrom K., Wolf F.W., Katz R., Li P., Dixit V.M.J. Biol. Chem. 266:12821-12824(1991)
The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein.Simantov R., Febbraio M., Silverstein R.L.Matrix Biol. 24:27-34(2005)
ncbi acc num :
NP_035711.2
ncbi gb acc num :
NM_011581.3
ncbi pathways :
ECM-receptor Interaction Pathway (83265); ECM-receptor Interaction Pathway (479); Focal Adhesion Pathway (198353); Focal Adhesion Pathway (83264); Focal Adhesion Pathway (478); Malaria Pathway (152666); Malaria Pathway (152657); PI3K-Akt Signaling Pathway (692242); PI3K-Akt Signaling Pathway (692979); Phagosome Pathway (153914)
uniprot summary :
THBS2: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD); also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain. Belongs to the thrombospondin family. Protein type: Motility/polarity/chemotaxis. Cellular Component: basement membrane; extracellular matrix; extracellular region; proteinaceous extracellular matrix. Molecular Function: calcium ion binding; heparin binding; protein binding. Biological Process: cell adhesion; negative regulation of angiogenesis; positive regulation of synaptogenesis