antibody

TAP2 Polyclonal Antibody

MBS126546

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry, immunocytochemistry

Antibody

TAP2 Polyclonal Antibody

[TAP2]

[APT2; PSF2; ABC18; ABCB3; PSF-2; RING11; D6S217E]

[Antigen peptide transporter 2; Antigen peptide transporter 2; antigen peptide transporter 2; ABC transporter, MHC 2; peptide supply factor 2; peptide transporter PSF2; really interesting new gene 11 protein; transporter 2, ABC (ATP binding cassette); peptide transporter involved in antigen processing 2; ATP-binding cassette, sub-family B (MDR/TAP), member 3; transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter PSF2; PSF-2; Peptide transporter TAP2; Peptide transporter involved in antigen processing 2; Really interesting new gene 11 protein]

[TAP2]

[TAP2; TAP2; APT2; PSF2; ABC18; ABCB3; PSF-2; RING11; D6S217E; ABCB3; PSF2; RING11; Y1; APT2; PSF-2]

TAP2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

686

Affinity Purification

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

WB: 1:500 - 1:2000. IHC: 1:50 - 1:200. IF: 1:50 - 1:200

Western Blot (WB)

Immunofluorescence (IF)

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 430-680 of human TAP2 (NP_000535.3).

Polyclonal

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Jul 2008]

549044

Q03519.1

Q03519

Calculated: 72kDa/75kDa. Observed: 76kDa

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); Adaptive Immune System Pathway (366160); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); ER-Phagosome Pathway (477124); Herpes Simplex Infection Pathway (377873)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

TAP2: a transporter associated with antigen processing (TAP) protein. Member of the ATP binding cassette (ABC) family of transmembrane transporters. Transports peptides across the endoplasmic reticulum membrane for assembly of major histocompatibility complex class I molecules. Two subunits, TAP1 and TAP2, are required for peptide transport. ATP hydrolysis is important for transport activity. Nascent MHC class I molecules associate with TAP via tapasin. Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: endoplasmic reticulum membrane; TAP complex; membrane; integral to membrane; integral to endoplasmic reticulum membrane. Molecular Function: tapasin binding; protein binding; peptide transporter activity; TAP1 binding; transporter activity; peptide antigen-transporting ATPase activity; ATP binding. Biological Process: intracellular transport of viral proteins in host cell; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class I; cytosol to ER transport; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I; peptide antigen transport; transmembrane transport; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Bare Lymphocyte Syndrome, Type I

0.05 mL

200 USD

0.1 mL

275

0.2 mL

430